Results 151 to 160 of about 656,203 (309)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Mark Poster Letter to Kurt Forster, May 23, 1991
Original file path: CTI_emails\CT-1991\FORSTEROriginal digital files were selected and transferred by Mark Poster to UCI Libraries via a portable hard drive then converted to PDF/A format by UCI Libraries' staff for access and preservation. Original file
Poster, Mark
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Mark Poster Letter to Louis Marin, January 19, 1988
Original file path: CTI_emails\CT-1988\MARIN2Original digital files were selected and transferred by Mark Poster to UCI Libraries via a portable hard drive then converted to PDF/A format by UCI Libraries' staff for access and preservation.
Poster, Mark
core
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Mark Poster Letter to Jennifer Crewe, May 13, 1989
Original file path: CTI_emails\CT-1989\JCREWOriginal digital files were selected and transferred by Mark Poster to UCI Libraries via a portable hard drive then converted to PDF/A format by UCI Libraries' staff for access and preservation.
Poster, Mark
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Mark Poster Letter to Juliet Mitchell, January 21, 1988
Original file path: CTI_emails\CT-1988\MITCHEL2Original digital files were selected and transferred by Mark Poster to UCI Libraries via a portable hard drive then converted to PDF/A format by UCI Libraries' staff for access and preservation.
Poster, Mark
core