Results 101 to 110 of about 60,184 (217)

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]

, 2017
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J, Durinck, Steffen, Friedman, Brad A, Ha, Connie, Liu, Jinfeng, Modrusan, Zora, Rubenstein, John L, Seshagiri, Somasekar   +7 more
core   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor

Cell Reports, 2019
Summary: The adult mouse brain contains an extensive neurogenic niche in the lateral walls of the lateral ventricles. This epithelium, which has a unique pinwheel organization, contains multiciliated ependymal (E1) cells and neural stem cells (B1).
Stephanie A. Redmond, María Figueres-Oñate, Kirsten Obernier, Marcos Assis Nascimento, Jose I. Parraguez, Laura López-Mascaraque, Luis C. Fuentealba, Arturo Alvarez-Buylla   +7 more
doaj   +1 more source

From fix to fit into the autoptic human brains. [PDF]

, 2018
Formalin-fixed, paraffinembedded (FFPE) human brain tissues are very often stored in formalin for long time. Formalin fixation reduces immunostaining, and the DNA/RNA extraction from FFPE brain tissue becomes suboptimal.
Lavezzi, A., Paradiso, B, Simonato, M
core   +1 more source

Exposure to anesthesia during delivery and risk of autism spectrum disorder: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Cesarean delivery with general anesthesia was associated with a modestly increased risk of autism in offspring compared to vaginal delivery while cesarean delivery with neuraxial anesthesia was not. Similar findings were seen across different surgery types and ethnic groups, suggesting that general anesthesia may be relevant to autism risk.
Aviv Ben Kish, Yair Binyamin, Analya Michaelovski, Gal Meiri, Idan Menashe   +4 more
wiley   +1 more source

Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid

Stem Cell Reports, 2015
Prenatal exposure to valproic acid (VPA), an established antiepileptic drug, has been reported to impair postnatal cognitive function in children born to VPA-treated epileptic mothers.
Berry Juliandi, Kentaro Tanemura, Katsuhide Igarashi, Takashi Tominaga, Yusuke Furukawa, Maky Otsuka, Noriko Moriyama, Daigo Ikegami, Masahiko Abematsu, Tsukasa Sanosaka, Keita Tsujimura, Minoru Narita, Jun Kanno, Kinichi Nakashima   +13 more
doaj   +1 more source

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. [PDF]

, 2018
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease.
A Fahrner, AD Workman, Antonio J. Gutierrez, Arantxa Cebrian-Silla, Arnold R. Kriegstein, Arturo Alvarez-Buylla, AS Hill, B Seri, B Steiner, C Wang, CV Dennis, Dashi Qi, David James, DR Kornack, DR Kornack, E Gould, E Gould, Edward F. Chang, Eric J. Huang, G Kempermann, Gary W. Mathern, GW Mathern, H Suh, H van Praag, H van Praag, HJ Kang, J Altman, J Altman, JE Malberg, JJ Breunig, Jose Manuel Garcia-Verdugo, Julia Chang, Kadellyn Sandoval, Kevin W. Kelley, KJ Mathews, KL Spalding, Kurtis I. Auguste, M Komitova, M Venere, Mercedes F. Paredes, MF Eckenhoff, Michael C. Oldham, N Patzke, N Sanai, P Yang, PS Eriksson, R Knoth, S Lugert, Shawn F. Sorrells, Simone Mayer, T Sugiyama, TE Bakken, Y Zhang, Zhengang Yang   +53 more
core   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Loss of the neurodevelopmental disease-associated gene miR-146a impairs neural progenitor differentiation and causes learning and memory deficits

Molecular Autism, 2020
Background Formation and maintenance of appropriate neural networks require tight regulation of neural stem cell proliferation, differentiation, and neurogenesis.
Julien Fregeac, Stéphanie Moriceau, Antoine Poli, Lam Son Nguyen, Franck Oury, Laurence Colleaux   +5 more
doaj   +1 more source

Neuron numbers increase in the human amygdala from birth to adulthood, but not in autism. [PDF]

, 2018
Remarkably little is known about the postnatal cellular development of the human amygdala. It plays a central role in mediating emotional behavior and has an unusually protracted development well into adulthood, increasing in size by 40% from youth to ...
Amaral, David G, Avino, Thomas A, Barger, Nicole, Bauman, Melissa D, Carlson, Erin L, Schumann, Cynthia M, Vargas, Martha V   +6 more
core   +1 more source