Results 131 to 140 of about 60,184 (217)

Early sensorimotor restriction in rats induces age‐dependent mitochondrial alterations in skeletal muscles and brain structures

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to determine whether early sensorimotor restriction (SMR) alters mitochondrial enzyme activities in rat muscles and brain structures. SMR was induced via immobilizing the hind limbs of pups for 16 h per day during the dark phase from birth to postnatal day (PND) 28.
Mélanie Van Gaever, Olivier Dupuy, Erwan Dupont, Marie‐Hélène Canu, Frederic Daussin   +4 more
wiley   +1 more source

Low-Dose Sevoflurane Promotes Hippocampal Neurogenesis and Facilitates the Development of Dentate Gyrus-Dependent Learning in Neonatal Rats

ASN Neuro, 2015
Huge body of evidences demonstrated that volatile anesthetics affect the hippocampal neurogenesis and neurocognitive functions, and most of them showed impairment at anesthetic dose.
Chong Chen, Feng-Yan Shen, Xuan Zhao, Tao Zhou, Dao-Jie Xu, Zhi-Ru Wang, Ying-Wei Wang   +6 more
doaj   +1 more source

Notch1 mediates postnatal neurogenesis in hippocampus enhanced by intermittent hypoxia

Neurobiology of Disease, 2014
Notch1 is a transcription factor on the membrane and regulates various stages of neurogenesis. Recently, studies have shown that in vitro neurogenesis is enhanced by hypoxia, and there is cross-coupling between Notch and hypoxia signaling pathways in vitro.
Kuan Zhang, Tong Zhao, Xin Huang, Li-ying Wu, Kuiwu Wu, Ling-ling Zhu, Ming Fan   +6 more
openaire   +3 more sources

Distinct developmental dynamics of opposing persistent currents shape motoneuron firing during motor maturation of zebrafish

The Journal of Physiology, EarlyView.
Abstract figure legend During the first few days of development, zebrafish acquire the ability to produce increasingly refined movements that rely progressively less on the activity of primary motoneurons. At the same time, primary motoneurons undergo functional maturation, becoming increasingly capable of repetitive firing.
Stephanie F. Gaudreau, Tuan V. Bui
wiley   +1 more source

Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog. [PDF]

, 2020
Neural stem cells (NSCs) in the prenatal neocortex progressively generate different subtypes of glutamatergic projection neurons. Following that, NSCs have a major switch in their progenitor properties and produce γ-aminobutyric acid (GABAergic ...
Bhaduri, Aparna, Chen, Bin, Du, Heng, Guo, Teng, He, Miao, Kriegstein, Arnold R, Li, Xiaosu, Li, Zhenmeiyu, Liang, Xiaoyi G, Liu, Guoping, Rubenstein, John L, Tsyporin, Jeremiah, Xu, Zhejun, Yang, Lin, Yang, Zhengang, Zhang, Yue, Zhang, Zhuangzhi   +16 more
core  

Maternal Milk Allopregnanolone May Buffer Negative Associations Between Maternal Postpartum Psychological Distress and Infant Regulatory Capacity

Developmental Psychobiology, Volume 68, Issue 2, March 2026.
ABSTRACT Maternal psychological distress during pregnancy and the early postpartum period is a risk factor for dysregulated affective and regulatory function in young infants. Animal models suggest that perinatal stress may alter offspring development via allopregnanolone (ALLO) exposure.
Denise M. Werchan, Bradley Susskind, Rebecca Carpio, Brittany R. Howell, Natalie H. Brito, Moriah E. Thomason   +5 more
wiley   +1 more source

Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice. [PDF]

Cell Rep, 2022
Aloi MS, Thompson SJ, Quartapella N, Noebels JL.   +3 more
europepmc   +1 more source

Precocial Weaning Influences Anxiety, Social and Maternal Care but Not Cognition in African Striped Mice, Rhabdomys dilectus chakae

Developmental Psychobiology, Volume 68, Issue 2, March 2026.
ABSTRACT Weaning is a stressful stage in the lives of young mammals. Early weaning, in particular, can lead to long‐lasting physiological and psychological changes. We investigated the effects of precocial weaning on anxiety, social behavior, cognition, and maternal behavior in adult African four‐striped mice (Rhabdomys dilectus chakae). Mice weaned at
Maria K Oosthuizen, Neville Pillay
wiley   +1 more source

Foxg1 Defines Ventrolateral Zonal Identity by Sustaining Neurogenic Progenitor Potential in the Olfactory Epithelium

Genes to Cells, Volume 31, Issue 2, March 2026.
Foxg1 maintains neurogenic progenitor potential in the ventrolateral olfactory epithelium. In control (Foxg1‐cHET) embryos, Foxg1‐expressing progenitors preferentially generate olfactory sensory neurons (OSNs) and support V‐zone expansion. Conditional Foxg1 deletion (Foxg1‐cKO) reduces V‐zone growth and shifts progenitor fate toward sustentacular cells
Anzu Kuriyama, Yuta Furusho, Carina Hanashima   +2 more
wiley   +1 more source

Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome

Immunology, Volume 177, Issue 3, Page 596-612, March 2026.
Decreased fetal brain macrophages were previously reported in Ts1Cje mice, a model of Down syndrome (DS). We confirmed the reduction in primitive macrophages, brain macrophage precursors, using Ts1Cje‐derived mouse embryonic stem cells (Ts1Cje‐mESCs) and human induced pluripotent stem cells with trisomy 21 (Tri21‐hiPSCs), with in vivo validation ...
Koki Harada, Keiichi Ishihara, Sayaka Wakayama, Teruhiko Wakayama, Sae Yamamoto, Haruhiko Sago, Shun Shimohama, Satoshi Akiba, Florent Ginhoux, Kazuyuki Takata   +9 more
wiley   +1 more source