Results 31 to 40 of about 1,201,455 (266)

Concrete Structure Inspired 3D‐Printed Framework Mechanically Reinforced Zwitterionic Hydrogel for Efficient Postoperative Abdominal Adhesion Prevention

Advanced Science, EarlyView.
Inspired by the establishment process and structure of concrete, a 3D‐printed PCL framework‐reinforced composite hydrogel is developed to overcome the mechanical limits of the original zwitterionic hydrogel toward clinic application of postoperative adhesion prevention.
Jianguo Song, Xin Cao, Ruirui Zhang, Shujie Cheng, Yi Wang   +4 more
wiley   +1 more source

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, EarlyView.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

Intravenous non-opioid analgesia for peri- and postoperative pain management: a scientific review of intravenous acetaminophen and ibuprofen

Korean Journal of Anesthesiology, 2015
Pain is a predictable consequence following operations, but the management of postoperative pain is another challenge for anesthesiologists and inappropriately controlled pain may lead to unwanted outcomes in the postoperative period.
W. Koh, Kimngan Nguyen, J. Jahr
semanticscholar   +1 more source

Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury

Advanced Science, EarlyView.
This study demonstrates that a hydrogel with mechanical properties matching the spinal cord directs fibroblast alignment, reshaping fibrotic scars into parallel matrices. A specific fibroblast subset mediates extracellular matrix remodeling through mechanotransduction, promoting axonal regeneration and neural reconnections, revealing potential ...
Longyou Xiao, Kaixi Shi, Wen Li, Jialin Liu, Pengfei Xie, Zijun Hu, Yu Dai, Haiyan Weng, Qiuju Yuan, Wutian Wu, Limin Rong, Liumin He   +11 more
wiley   +1 more source

Bone Marrow Mesenchymal Stem Cell Hydrogel‐Mediated Fibroblast Reprogramming Restores Intestinal Function in Adhesive Small Bowel Obstruction

Advanced Science, EarlyView.
Conceptual diagram and schematic illustration of microenvironmental changes in individuals with ASBO before and after treatment. BMSC@Gel therapy transforms the ASBO microenvironment from an inflammatory, fibrotic state with aberrant matrix deposition and barrier dysfunction to a regenerative state with reduced inflammation and improved structural ...
Lihong Zheng *, Junrong Zhang *, Zhengyuan Huang *, Zhenliang Lin, Jin Zhang, Da Zhang, Ping Hou, Xianqiang Chen   +7 more
wiley   +1 more source

Efficacy of Local Bupivacaine Injection of Postoperative Pain in Endoscopic Sinus Surgery

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Regional anesthesia is effective in alleviating postoperative pain and reducing the requirement for systemic pain medications. However, optimal postoperative pain management in endoscopic sinus surgery (ESS) remains challenging.
Wiracha Leewannapasai, Navarat Tangbumrungtham, Kanokporn Sarsitthithum, Kangsadarn Tanjararak, Boonsam Roongpuvapaht   +4 more
wiley   +1 more source

Perineural Dexamethasone to Improve Postoperative Analgesia with Peripheral Nerve Blocks: A Meta-Analysis of Randomized Controlled Trials

Pain Research and Treatment, 2014
Background. The overall effect of perineural dexamethasone on postoperative analgesia outcomes has yet to be quantified. The main objective of this quantitative review was to evaluate the effect of perineural dexamethasone as a nerve block adjunct on ...
Gildàsio S. de Oliveira, L. C. Castro Alves, A. Nader, M. Kendall, Rohit Rahangdale, R. McCarthy   +5 more
semanticscholar   +1 more source

Evaluation of a modified triple‐combination anesthesia using dexmedetomidine in mice

Animal Models and Experimental Medicine, EarlyView.
Development of a modified ketamine‐free anesthetic (dMMB) using dexmedetomidine. To improve the safety and recovery profile of conventional MMB, we developed dMMB by replacing medetomidine with dexmedetomidine. This ketamine‐free formulation showed comparable anesthetic depth and enhanced thermoregulation, avoiding unnecessary isomers for safer use ...
Masaki Watanabe, Ryosuke Nakanishi, Tomoki Omori, Takeru Sasaki, Atsushi Asano, Nobuya Sasaki   +5 more
wiley   +1 more source

Synergistic Effects of Dexamethasone and Dexmedetomidine in Extending the Effects of Pectoral I and Pectoral II Blocks for Postoperative Analgesia Following Total Mastectomy with Lymph Node Dissection [PDF]

, 2021
Ahish Chitneni, Jamal Hasoon, Ivan Urits, Omar Viswanath, Alan D. Kaye, Jonathan P. Eskander   +5 more
openalex   +1 more source