Results 91 to 100 of about 10,704,455 (290)

Highly Nonrandom Features of Synaptic Connectivity in Local Cortical Circuits

PLoS Biology, 2005
How different is local cortical circuitry from a random network? To answer this question, we probed synaptic connections with several hundred simultaneous quadruple whole-cell recordings from layer 5 pyramidal neurons in the rat visual cortex.
Sen Song, P. J. Sjöström, Markus Reigl, S. Nelson, D. Chklovskii   +4 more
semanticscholar   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Concurrent validity of dynamic bedside quantitative sensory testing paradigms in breast cancer survivors with persistent pain

Scandinavian Journal of Pain
Studies on the concurrent validity of clinically applicable testing protocols for conditioned pain modulation (CPM) and temporal summation of pain (TSP) in breast cancer survivors (BCS) with persistent pain are lacking.
Haenen Vincent, Meeus Mira, Devoogdt Nele, Morlion Bart, Dams Lore, De Groote Amber, Foubert Anthe, De Groef An   +7 more
doaj   +1 more source

Active integration of glutamatergic input to the inferior olive generates bidirectional postsynaptic potentials [PDF]

, 2016
Derek L.F. Garden, Arianna Rinaldi, Matthew F. Nolan   +2 more
openalex   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Selective activation of BK channels in small-headed dendritic spines suppresses excitatory postsynaptic potentials [PDF]

, 2021
Sabrina Tazerart, Maxime G. Blanchard, Soledad Miranda‐Rottmann, Diana Mitchell, Bruno Navea Pina, Connon I. Thomas, Naomi Kamasawa, Roberto Araya   +7 more
openalex   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Effect of standing posture on inhibitory postsynaptic potentials in gastrocnemius motoneurons [PDF]

, 2018
S. Jayne Garland, Alessio Gallina, Courtney L. Pollock, Tanya D. Ivanova   +3 more
openalex   +1 more source

A Van Der Waals Broadband Infrared Optical Synapse Enabling Orientation Detection

Advanced Science, EarlyView.
An infrared optoelectronic synapse based on a graphene/CrOCl/graphene van der Waals heterostructure is reported to possess a broadband synaptic response range from the visible to the infrared (520–2000 nm), which can be used to achieve orientation and motion detections of a target mimicing the pit organ of a pit vapor.
Dan Guo, Wenjing Li, Pingfan Gu, Weikang Dong, Xuyan Rui, Kenji Watanabe, Takashi Taniguchi, Yu Ye, Fawei Zheng, Jiadong Zhou, Shoujun Zheng   +10 more
wiley   +1 more source