Results 91 to 100 of about 10,231,702 (322)

Molecular model of postsynaptic potential.

Proceedings of the National Academy of Sciences of the United States of America, 1975
A molecular model of the excitatory postsynaptic membrane is given in terms of two biochemical cycles intimately associated: an acetylcholine cycle and a calcium cycle.
D. Dubois, E. Schoffeniels
semanticscholar   +1 more source

Detecting and Estimating Signals over Noisy and Unreliable Synapses: Information-Theoretic Analysis [PDF]

, 2001
The temporal precision with which neurons respond to synaptic inputs has a direct bearing on the nature of the neural code. A characterization of the neuronal noise sources associated with different sub-cellular components (synapse, dendrite, soma, axon,
Koch, Christof, Manwani, Amit
core  

Postsynaptic protein kinase a reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS [PDF]

, 2003
Previous work has identified a role for synaptic activity in the development of excitable properties of motoneurons in the Drosophila embryo. In this study the underlying mechanism that enables two such neurons, termed aCC and RP2, to respond to ...
Baines, Richard A.
core   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Alterations in brain connectivity due to plasticity and synaptic delay

, 2017
Brain plasticity refers to brain's ability to change neuronal connections, as a result of environmental stimuli, new experiences, or damage. In this work, we study the effects of the synaptic delay on both the coupling strengths and synchronisation in a ...
Batista, A. M., Borges, F. S., Borges, R. R., Caldas, I. L., Iarosz, K. C., Lameu, E. L., Macau, E. E. N., Protachevicz, P. R., Viana, R. L.   +8 more
core   +1 more source

Characteristics of long-duration inhibitory postsynaptic potentials in rat neocortical neurons in vitro [PDF]

, 1987
1. The characteristics of long-duration inhibitory postsynaptic potentials (l-IPSPs) which are evoked in rat frontal neocortical neurons by local electrical stimulation were investigated with intracellular recordings from anin vitro slice preparation.
A. Constanti, B. E. Alger, B. W. Connors, Bernd Sutor, J. R. Hotson, J. R. Howe, J. R. Howe, James R. Howe, M. Galvan, M. McCarren, M. Satou, N. R. Newberry, P. A. Schwartzkroin, R. H. Thalmann, R. H. Thalmann, W. D. Knowles, Walter Zieglg�nsberger, Y. Fujita   +17 more
core   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Imbalance of Excitation and Inhibition at Threshold Level In the Auditory Cortex

Frontiers in Neural Circuits, 2015
The interplay of cortical excitation and inhibition is a fundamental feature of cortical information processing. Excitation and inhibition in single cortical neurons are balanced in their response to optimal sensory stimulation due to thalamocortical ...
Yan eZhao, Yan eZhao, Zizhen eZhang, Xiuping eLiu, Colin eXiong, Zhongju eXiao, Jun eYan   +6 more
doaj   +1 more source

Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus

Molecular Brain, 2020
The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for axon guidance during development and are expressed by neurons in the mature brain.
Stephen D. Glasgow, Edwin W. Wong, Greta Thompson-Steckel, Nathalie Marcal, Philippe Séguéla, Edward S. Ruthazer, Timothy E. Kennedy   +6 more
doaj   +1 more source

A53T Mutant Alpha-Synuclein Induces Tau-Dependent Postsynaptic Impairment Independently of Neurodegenerative Changes

Journal of Neuroscience, 2018
Abnormalities in α-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Because α-synuclein is highly concentrated within presynaptic terminals, presynaptic dysfunction has been proposed as a potential pathogenic mechanism.
Peter J. Teravskis, A. Covelo, Eric C. Miller, Balvindar Singh, Héctor A. Martell-Martínez, M. Benneyworth, Christopher Gallardo, Breeta R. Oxnard, A. Araque, Michael K. Lee, D. Liao   +10 more
semanticscholar   +1 more source