Results 101 to 110 of about 10,517,225 (330)

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

open access: yesAdvanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni   +14 more
wiley   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

open access: yesAdvanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen   +9 more
wiley   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

open access: yesAdvanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang   +19 more
wiley   +1 more source

Electrokinetic mechanism of miniature postsynaptic potentials. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1966
Walter J. Moore, Ludvik Bass
openaire   +3 more sources

Aptamer‐Mediated Artificial Synapses for Neuromorphic Modulation of Inflammatory Signaling via Organic Electrochemical Transistor

open access: yesAdvanced Science, EarlyView.
An aptamer‐mediated neuromorphic interface based on organic electrochemical transistors selectively transduces interleukin‐6 (IL‐6) signals into neuromorphic electrical outputs. This protein‐driven neuromorphic plasticity, responsive in physiological and in vivo environmental electrolyte, bridges biochemical signaling with artificial neural encoding ...
Yuqing Ding   +11 more
wiley   +1 more source

Activity-dependent refinement of axonal projections forms one-to-one connection pattern in the developing chick ciliary ganglion

open access: yesFrontiers in Cellular Neuroscience
Although it is well established that initially overproduced synaptic connections are extensively remodeled through activity-dependent competition for postsynaptic innervation, the mechanisms determining the final number of postsynaptic targets per axon ...
Ryo Egawa, Hiromu Yawo, Hiroshi Kuba
doaj   +1 more source

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