Results 11 to 20 of about 117,832 (333)
Posttranslational modifications of the cytoskeleton [PDF]
Cytoskeleton, 2021 AbstractThe cytoskeleton plays important roles in many essential processes at the cellular and organismal levels, including cell migration and motility, cell division, and the establishment and maintenance of cell and tissue architecture. In order to facilitate these varied functions, the main cytoskeletal components—microtubules, actin filaments, and ...
Brittany MacTaggart, Anna Kashina
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Posttranslational Modifications in Ferroptosis [PDF]
Oxidative Medicine and Cellular Longevity, 2020 Ferroptosis was first coined in 2012 to describe the form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. To date, ferroptosis has been implicated in many diseases, such as carcinogenesis, degenerative diseases (e.g., Huntington’s, Alzheimer’s, and Parkinson’s diseases), ischemia-reperfusion injury, and cardiovascular ...
Xiang Wei +3 more
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The Degradation Pathway of the Mitophagy Receptor Atg32 Is Re-Routed by a Posttranslational Modification. [PDF]
PLoS ONE, 2016 The outer mitochondrial membrane protein Atg32 is the central receptor for mitophagy, the mitochondria-specific form of autophagy. Atg32 is an unstable protein, and is rapidly degraded under conditions in which mitophagy is not induced. Here we show that
Mariia Levchenko +2 more
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Role of Glycoproteins during Fruit Ripening and Seed Development
Cells, 2021 Approximately thirty percent of the proteins synthesized in animal or plant cells travel through the secretory pathway. Seventy to eighty percent of those proteins are glycosylated. Thus, glycosylation is an important protein modification that is related
Angela Mendez-Yañez +2 more
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Glycosylation—The Most Diverse Post-Translational Modification
Biomolecules, 2022 This article is part of the Special Issue Glycosylation—The Most Diverse Post-Translational Modification [...]
Erika Staudacher +2 more
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Posttranslational modifications of tissue factor [PDF]
Frontiers in Bioscience, 2012 Tissue factor (TF), a membrane protein, is an initiator of blood coagulation in vivo. In this review we discuss how posttranslational modifications affect activity and other properties of TF. Glycosylation of the extracellular domain and the composition of carbohydrates at three glycosylation sites have an influence on TF activity in the extrinsic ...
Kenneth G. Mann +2 more
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Posttranslational modifications in pathogenesis of PCOS
Frontiers in Endocrinology, 2022 Polycystic ovary syndrome (PCOS) is a lifelong reproductive, metabolic, and psychiatric disorder that affects 5-18% of women, which is associated with a significantly increased lifetime risk of concomitant diseases, including type 2 diabetes, psychiatric disorders, and gynecological cancers. Posttranslational modifications (PTMs) play an important role
Huimei Wei +4 more
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Asian Journal of Urology, 2020 Prostate cancer (PCa) is the most commonly diagnosed cancer among men in western countries. Androgen receptor (AR) signaling plays key roles in the development of PCa. Androgen deprivation therapy (ADT) remains the standard therapy for advanced PCa.
Simeng Wen, Yuanjie Niu, Haojie Huang
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Posttranslational Protein Modification in Archaea [PDF]
Microbiology and Molecular Biology Reviews, 2005 SUMMARYOne of the first hurdles to be negotiated in the postgenomic era involves the description of the entire protein content of the cell, the proteome. Such efforts are presently complicated by the various posttranslational modifications that proteins can experience, including glycosylation, lipid attachment, phosphorylation, methylation, disulfide ...
Jerry Eichler, Michael W. W. Adams
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Posttranslational Modifications in Connexins and Pannexins [PDF]
The Journal of Membrane Biology, 2012 Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring proper protein life cycle and function.
Johnstone, Scott +4 more
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