Results 11 to 20 of about 119,060 (284)

Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification

Biomolecules, 2023
p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important regulator in regulating the evolution of malignant ...
Qingmei Zeng, Kun Wang, Yongxiang Zhao, Qingzhi Ma, Zhinan Chen, Wan Huang   +5 more
doaj   +1 more source

The Degradation Pathway of the Mitophagy Receptor Atg32 Is Re-Routed by a Posttranslational Modification. [PDF]

PLoS ONE, 2016
The outer mitochondrial membrane protein Atg32 is the central receptor for mitophagy, the mitochondria-specific form of autophagy. Atg32 is an unstable protein, and is rapidly degraded under conditions in which mitophagy is not induced. Here we show that
Mariia Levchenko, Isotta Lorenzi, Jan Dudek   +2 more
doaj   +1 more source

Role of Glycoproteins during Fruit Ripening and Seed Development

Cells, 2021
Approximately thirty percent of the proteins synthesized in animal or plant cells travel through the secretory pathway. Seventy to eighty percent of those proteins are glycosylated. Thus, glycosylation is an important protein modification that is related
Angela Mendez-Yañez, Patricio Ramos, Luis Morales-Quintana   +2 more
doaj   +1 more source

Glycosylation—The Most Diverse Post-Translational Modification

Biomolecules, 2022
This article is part of the Special Issue Glycosylation—The Most Diverse Post-Translational Modification [...]
Erika Staudacher, Els J. M. Van Damme, Guy Smagghe   +2 more
doaj   +1 more source

Comparative genomics of Burkholderia multivorans, a ubiquitous pathogen with a highly conserved genomic structure [PDF]

, 2017
The natural environment serves as a reservoir of opportunistic pathogens. A well-established method for studying the epidemiology of such opportunists is multilocus sequence typing, which in many cases has defined strains predisposed to causing infection.
Peeters, Charlotte, Cooper, Vaughn S, Hatcher, Philip J, Verheyde, Bart, Carlier, Aurélien, Vandamme, Peter   +5 more
core   +8 more sources

Posttranslational regulation of androgen dependent and independent androgen receptor activities in prostate cancer

Asian Journal of Urology, 2020
Prostate cancer (PCa) is the most commonly diagnosed cancer among men in western countries. Androgen receptor (AR) signaling plays key roles in the development of PCa. Androgen deprivation therapy (ADT) remains the standard therapy for advanced PCa.
Simeng Wen, Yuanjie Niu, Haojie Huang
doaj   +1 more source

Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A [PDF]

, 2017
Ribosomal translation factors are fundamental for protein synthesis and highly conserved in all kingdoms of life. The essential eukaryotic elongation factor 1A (eEF1A) delivers aminoacyl tRNAs to the A-site of the translating 80S ribosome.
Aktories, Klaus, Andersen, Gregers Rom, Belyi, Yury, Dengjel, Jörn, Hu, Zehan, Hunte, Carola, Jank, Thomas, Rospert, Sabine, Schlosser, Andreas, Tzivelekidis, Tina, Wirth, Christophe   +10 more
core   +1 more source

Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation [PDF]

, 2020
An inverse electron demand Diels–Alder reaction between tetrazine and trans-cyclooctene (TCO) holds great promise for protein modification and manipulation.
Chudasama, V., Kuan, S., Nogueira, J., Raabe, M., Weil, T., Xu, L., Zegota, M.   +6 more
core   +1 more source

Targeted Quantification of Phosphorylation Sites Identifies STRIPAK-Dependent Phosphorylation of the Hippo Pathway-Related Kinase SmKIN3

mBio, 2021
Phosphorylation and dephosphorylation of proteins are fundamental posttranslational modifications that determine the fine-tuning of their biological activity.
Valentina Stein, Bernhard Blank-Landeshammer, Ramona Märker, Albert Sickmann, Ulrich Kück   +4 more
doaj   +1 more source

Nitric oxide-induced calcium release: activation of type 1 ryanodine receptor, a calcium release channel, through non-enzymatic posttranslational modification by nitric oxide

Frontiers in Endocrinology, 2013
Nitric oxide (NO) is a typical gaseous messenger involved in a wide range of biological processes. In our classical knowledge, effects of NO are largely achieved by activation of soluble guanylyl cyclase to form cyclic guanosine-3’, 5’-monophosphate ...
Sho eKakizawa
doaj   +1 more source