Results 31 to 40 of about 120,482 (333)

Structure of the planar cell polarity cadherins Fat4 and Dachsous1

Nature Communications, 2023
Fat and Dachsous are large cadherins that regulate planar polarity as a receptor:ligand pair. Here, authors determine the structure of the Fat:Dachsous complex to uncover the molecular determinants of binding and posttranslational modification.
Elliot Medina, Yathreb Easa, Daniel K. Lester, Eric K. Lau, David Sprinzak, Vincent C. Luca   +5 more
doaj   +1 more source

Posttranslational Modifications of RAS Proteins [PDF]

Cold Spring Harbor Perspectives in Medicine, 2018
The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting.
Ian, Ahearn, Mo, Zhou, Mark R, Philips
openaire   +2 more sources

Posttranslational regulatory mechanism of PD-L1 in cancers and associated opportunities for novel small-molecule therapeutics

Acta Biochimica et Biophysica Sinica
Despite the tremendous progress in cancer research over the past few decades, effective therapeutic strategies are still urgently needed. Accumulating evidence suggests that immune checkpoints are the cause of tumor immune escape.
Cai Minchen, Xu Mengting, Yu Dianping, Wang Qun, Liu Sanhong   +4 more
doaj   +1 more source

Mammalian N1-adenosine PARylation is a reversible DNA modification

Nature Communications, 2022
Poly-ADP-ribosylation (PARylation) is a well-known posttranslational modification of proteins. Here the authors show that beyond proteins also mammalian single-stranded DNA is PARylated in vitro and in vivo.
Michael U. Musheev, Lars Schomacher, Amitava Basu, Dandan Han, Laura Krebs, Carola Scholz, Christof Niehrs   +6 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

SnapShot: p53 Posttranslational Modifications

Cell, 2008
Since p53 was cloned and subsequently characterized as a tumor suppressor more the 20 years ago, more than 40,000 publications have been published relating to this protein. A great majority of this scientific literature focuses on the intricate details of p53 regulation by posttranslational modifications.
Kruse, Jan-Philipp, Gu, Wei
openaire   +2 more sources

Posttranslational Modification and Quality Control [PDF]

Circulation Research, 2013
Protein quality control functions to minimize the level and toxicity of misfolded proteins in the cell. Protein quality control is performed by intricate collaboration among chaperones and target protein degradation. The latter is performed primarily by the ubiquitin-proteasome system and perhaps autophagy.
Xuejun, Wang, J Scott, Pattison, Huabo, Su   +2 more
openaire   +2 more sources

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis [PDF]

, 2018
Cytokinesis, the final phase of cell division, is necessary to form two distinct daughter cells with correct distribution of genomic and cytoplasmic materials.
A Konishi, A Verdina, AC Borisa, AT Lau, B Mierzwa, C Ditchfield, C Lazzari, C Mollinari, C Norden, C Rinaldo, C Rinaldo, C Rinaldo, C Rinaldo, Cinzia Rinaldo, CK Hu, D Valente, Davide Valente, E Gresko, F Siepi, G D’Orazi, G D’Orazi, G Normand, GE Atilla-Gokcumen, H Goto, HC Huang, I Vitale, JA Blaquiere, JM Cummins, JP Fededa, JR Bischoff, K Kobiyama, L Vega De la, Laura Monteonofrio, M Agromayor, M Carmena, M Glotzer, M Kollareddy, Manuela Ferrara, Marco Crescenzi, ME Douglas, ME Douglas, O Afonso, P Carpinelli, PP D’Avino, R Kuriyama, R Nunes Bastos, Roberta Miscione, S Francia, S Hauf, S Matt, Serena Camerini, Silvia Soddu, SM Lens, TD Pollard, TG Hofmann, TG Hofmann, V Bavetsias, VV Saul, VV Saul, WM Zhao, XL Li, Y Feng, Y Kuwano, Y Terada, YH Kim, Z Storchova   +65 more
core   +1 more source

The post-translational modification landscape of commercial beers

Scientific Reports, 2021
Beer is one of the most popular beverages worldwide. As a product of variable agricultural ingredients and processes, beer has high molecular complexity.
Edward D. Kerr, Christopher H. Caboche, Cassandra L. Pegg, Toan K. Phung, Claudia Gonzalez Viejo, Sigfredo Fuentes, Mark T. Howes, Kate Howell, Benjamin L. Schulz   +8 more
doaj   +1 more source

Tissue-Specific Posttranslational Modification Allows Functional Targeting of Thyrotropin

Cell Reports, 2014
Thyroid-stimulating hormone (TSH; thyrotropin) is a glycoprotein secreted from the pituitary gland. Pars distalis-derived TSH (PD-TSH) stimulates the thyroid gland to produce thyroid hormones (THs), whereas pars tuberalis-derived TSH (PT-TSH) acts on the
Keisuke Ikegami, Xiao-Hui Liao, Yuta Hoshino, Hiroko Ono, Wataru Ota, Yuka Ito, Taeko Nishiwaki-Ohkawa, Chihiro Sato, Ken Kitajima, Masayuki Iigo, Yasufumi Shigeyoshi, Masanobu Yamada, Yoshiharu Murata, Samuel Refetoff, Takashi Yoshimura   +14 more
doaj   +1 more source