Posttranslational modification of Elongation Factor P from Staphylococcus aureus [PDF]
FEBS Open Bio, 2020 Antibiotic‐resistant Staphylococcus aureus is becoming a major burden on health care systems in many countries, necessitating the identification of new targets for antibiotic development.
Alexander Golubev +6 more
doaj +4 more sources
Protein ISGylation: a posttranslational modification with implications for malignant neoplasms [PDF]
Exploration of Targeted Anti-tumor Therapy, 2023 Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation.
Angeles C. Tecalco-Cruz +1 more
doaj +4 more sources
Balancing acts: The posttranslational modification tightrope of flavivirus replication. [PDF]
PLoS PathogensPosttranslational modifications (PTMs) such as phosphorylation, ubiquitination, SUMOylation, and ISGylation are involved in various cellular pathways, including innate immunity and disease processes.
RuthMabel Boytz, Maudry Laurent-Rolle
doaj +3 more sources
Biomolecules, 2023 p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important regulator in regulating the evolution of malignant ...
Qingmei Zeng +5 more
doaj +2 more sources
Posttranslational Modification in Bone Homeostasis and Osteoporosis [PDF]
MedCommBone is responsible for providing mechanical protection, attachment sites for muscles, hematopoiesis micssroenvironment, and maintaining balance between calcium and phosphorate.
Yuzhe Lin +7 more
doaj +2 more sources
The Degradation Pathway of the Mitophagy Receptor Atg32 Is Re-Routed by a Posttranslational Modification. [PDF]
PLoS ONE, 2016 The outer mitochondrial membrane protein Atg32 is the central receptor for mitophagy, the mitochondria-specific form of autophagy. Atg32 is an unstable protein, and is rapidly degraded under conditions in which mitophagy is not induced. Here we show that
Mariia Levchenko +2 more
doaj +2 more sources
Posttranslational modifications of proopiomelanocortin in vertebrates and their biological significance [PDF]
Frontiers in Endocrinology, 2013 Proopiomelanocortin (POMC) is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation,
Akiyoshi eTakahashi, Kanta eMizusawa
doaj +2 more sources
Posttranslational microtubule modification alters podocalyxin-trafficking in epithelial cells
Frontiers in Cell and Developmental BiologyEpithelial polarization is characterized by separation of the plasma membrane into an apical and a basolateral membrane domain. This morphology is verified by cytoskeletal organization that stabilizes the cellular architecture and provides specific ...
Lena-Sophie Gorek +6 more
doaj +2 more sources
Editorial: Regulation of inflammation: metabolic reprogramming and posttranslational modification [PDF]
Frontiers in ImmunologyZhengyu Jiang +3 more
doaj +2 more sources
A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins. [PDF]
J Am Chem SocPosttranslational modifications (PTMs) of proteins play central roles in regulating protein structure, interactome, and functions. A notable modification site is the aromatic side chain of Tyr, which undergoes modifications, such as phosphorylation and ...
Lin X +6 more
europepmc +3 more sources