Results 71 to 80 of about 120,482 (333)

Transcriptome Profiling and Bioinformatic Analysis of the Fourth-Stage Larvae of Angiostrongylus cantonensis

Iranian Journal of Parasitology, 2022
Background: To explore the transcriptome profiling of the fourth-stage larvae of Angiostrongylus cantonensis. Methods: Two groups of fourth-stage larvae were collected to extract total RNA in Zhejiang, China 2020. Then, mRNA was separated and reverse
Yue Guo, Hui Zhang, Haiyan Dong, Ming Ke Lu, Xiaoyu Li   +4 more
doaj   +1 more source

Posttranslational Protein Modification inArchaea [PDF]

Microbiology and Molecular Biology Reviews, 2005
SUMMARYOne of the first hurdles to be negotiated in the postgenomic era involves the description of the entire protein content of the cell, the proteome. Such efforts are presently complicated by the various posttranslational modifications that proteins can experience, including glycosylation, lipid attachment, phosphorylation, methylation, disulfide ...
Jerry, Eichler, Michael W W, Adams
openaire   +3 more sources

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. [PDF]

, 2019
Amyloid-β (Aβ) harbors numerous posttranslational modifications (PTMs) that may affect Alzheimer's disease (AD) pathogenesis. Here we present the 1.1 Å resolution MicroED structure of an Aβ 20-34 fibril with and without the disease-associated PTM, L ...
Boyer, David R, Cascio, Duilio, Clarke, Steven G, Eisenberg, David S, Gonen, Tamir, Richards, Logan S, Sawaya, Michael R, Warmack, Rebeccah A, Zee, Chih-Te   +8 more
core  

Enrichment and aggregation of topological motifs are independent organizational principles of integrated interaction networks

, 2011
Topological network motifs represent functional relationships within and between regulatory and protein-protein interaction networks. Enriched motifs often aggregate into self-contained units forming functional modules.
Anagha Joshi, Björklund, Brin, Bruno Nachtergaele, Csikász-Nagy, De Lathauwer, de Lichtenberg, Dobrin, Fiedler, Harbison, Hartwell, Huang, Kalir, Kashtan, Kashtan, Kellog, Kleinberg, Kraemer, Lee, Lee, Loch, Mazurie, McClellan, Mendenhall, Milo, Neely, Newman, Planta, Ptacek, Ravasz, Reguly, Shen-Orr, Solé, Solé, Spellman, Stark, Tan, Tom Michoel, Vázquez, Yeger-Lotem, Yeger-Lotem, Yosef, Yu, Yves Van de Peer, Zhang, Zhao   +45 more
core   +2 more sources

Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulation [PDF]

, 2006
The intrinsic properties of a neuron determine the translation of synaptic input to axonal output. It is this input– output relationship that is the heart of all nervous system activity.
Baines, Richard A., Hempel, Chris M., Li, L. (Lingjun), Liss, Birgit, Misonou, Hiroaki, Schulz, David J.   +5 more
core   +2 more sources

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Protein post-translational modification regulates HIV-1 latency

生物医学转化
AIDS is a disease named acquired immunodeficiency syndrome, which caused by the human immunodeficiency virus (HIV). HIV can be divided into HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is a global pandemic that has caused serious harm.
Wu Tong, Wang Tiantian, Deng Kai
doaj   +1 more source

Purification and properties of glyceraldehyde-3-phosphate dehydrogenase from the skeletal muscle of the hibernating ground squirrel, Ictidomys tridecemlineatus [PDF]

PeerJ, 2014
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the skeletal muscle of euthermic and torpid Ictidomys tridecemlineatus was purified to electrophoretic homogeneity using a novel method involving Blue-agarose and Phenyl-agarose chromatography ...
Ryan A.V. Bell, Jeffrey C. Smith, Kenneth B. Storey   +2 more
doaj   +2 more sources

y-mtPTM: Yeast mitochondrial posttranslational modification database [PDF]

, 2023
Broňa Brejová, Veronika Vozáriková, Ivan Agarský, Hana Derková, Matej Fedor, Dominika Harmanová, L. D. B. Kiss, Andrej Korman, Martin Pašen, Filip Brázdovič, Tomáš Vinař, Jozef Nosek, Ľubomír Tomáška   +12 more
openalex   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source