Results 81 to 90 of about 120,482 (333)
The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids [PDF]
, 2014 The posttranslational modification of carboxy-terminal tails of tubulin plays an important role in the regulation of the microtubule cytoskeleton. Enzymes responsible for deglutamylating tubulin have been discovered within a novel family of mammalian ...
Andrieux, Annie +10 more
core +5 more sources
Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome
Advanced Science, EarlyView.Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel +19 more
wiley +1 more source
Post-Translational Modification of WRKY Transcription Factors
PlantsPost-translational modifications (PTMs) of proteins are involved in numerous biological processes, including signal transduction, cell cycle regulation, growth and development, and stress responses. WRKY transcription factors (TFs) play significant roles
Xiangui Zhou, Zaojuan Lei, Pengtian An
doaj +1 more source
Post-translational Modification Control of HBV Biological Processes
Frontiers in Microbiology, 2018 Hepatitis B virus infection remains a global healthy issue that needs to be urgently solved. Novel strategies for anti-viral therapy are based on exploring the effective diagnostic markers and therapeutic targets of diseases caused by hepatitis B virus ...
Fan Yang
doaj +1 more source
Detecting Posttranslational Modifications of Hsp90 [PDF]
, 2017 The molecular chaperone Heat Shock Protein 90 (Hsp90) is essential in eukaryotes. Hsp90 chaperones proteins that are important determinants of multistep carcinogenesis. The chaperone function of Hsp90 is linked to its ability to bind and hydrolyze ATP.
Rebecca A, Sager +3 more
openaire +2 more sources
O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]
, 2015 Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R +8 more
core +2 more sources
Advanced Science, EarlyView.Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu +20 more
wiley +1 more source
How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]
, 2017 Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias +2 more
core +2 more sources
Advanced Science, EarlyView.In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang +19 more
wiley +1 more source
Angewandte Chemie, EarlyView.Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang +6 more
wiley +2 more sources