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The structure of the potassium channel: molecular basis of K+ conduction and selectivity.
Science, 1998The potassium channel from Streptomyces lividans is an integral membrane protein with sequence similarity to all known K+ channels, particularly in the pore region.
D. Doyle +7 more
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Potassium channels and epilepsy
Acta Neurologica Scandinavica, 2022With the development and application of next-generation sequencing technology, the aetiological diagnosis of genetic epilepsy is rapidly becoming easier and less expensive. Additionally, there is a growing body of research into precision therapy based on genetic diagnosis.
Kai, Gao +3 more
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IEEE Transactions on Nanobioscience, 2005
Potassium channels are integral membrane proteins that selectively transport K+ across the cell membrane. They are present in all mammalian cells and have a wide variety of roles in both excitable and nonexcitable cells. The phenotypic diversity required to accomplish their various roles is created by differences in conductance, the timecourse and ...
Stephen J, Korn, Josef G, Trapani
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Potassium channels are integral membrane proteins that selectively transport K+ across the cell membrane. They are present in all mammalian cells and have a wide variety of roles in both excitable and nonexcitable cells. The phenotypic diversity required to accomplish their various roles is created by differences in conductance, the timecourse and ...
Stephen J, Korn, Josef G, Trapani
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Trafficking of potassium channels
Current Opinion in Neurobiology, 2005Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the presence of two recently identified ...
Heusser, Katja, Schwappach, Blanche
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2021
Neoplastic transformation is reportedly associated with alterations of the potassium transport across plasma and intracellular membranes. These alterations have been identified as crucial elements of the tumourigenic reprogramming of cells. Potassium channels may contribute to cancer initiation, malignant progression and therapy resistance of tumour ...
Robert Lukowski +5 more
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Neoplastic transformation is reportedly associated with alterations of the potassium transport across plasma and intracellular membranes. These alterations have been identified as crucial elements of the tumourigenic reprogramming of cells. Potassium channels may contribute to cancer initiation, malignant progression and therapy resistance of tumour ...
Robert Lukowski +5 more
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Mitochondrial potassium channels
IUBMB Life, 2009AbstractMitochondrial potassium channels are believed to contribute to cytoprotection of injured cardiac and neuronal tissues. The following potassium channels have been described in the inner mitochondrial membrane: the ATP‐regulated potassium channel, the large conductance Ca2+‐activated potassium channel, the voltage‐gated Kv1.3 potassium channel ...
Adam Szewczyk +2 more
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Presynaptic potassium channels
Current Opinion in Neurobiology, 1996The past year has witnessed some significant improvements in our understanding of the molecular diversity, subunit composition, and functional properties of K+ channels in heterologous expression systems. Immunocytochemical studies have yielded important information on the localization of K+ channel proteins to synaptic terminals in mammalian brain ...
Olaf Pongs, Jochen Roeper
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Potassium channels in the vasculature
Current Opinion in Nephrology and Hypertension, 1998Many important cellular functions are regulated by vascular potassium channels, including the resting membrane potential. Recent evidence suggests that the function of these channels is altered in pathophysiological disorders of the cardiovascular system.
Andrew Tinker, Lucie H. Clapp
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Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia.
Physiological Reviews, 2014About 10 distinct potassium channels in the heart are involved in shaping the action potential. Some of the K+ channels are primarily responsible for early repolarization, whereas others drive late repolarization and still others are open throughout the ...
N. Schmitt, M. Grunnet, S. Olesen
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Pharmacology of Potassium Channels
1997Publisher Summary Potassium channels represent the largest and most diverse family of ion channels. K+ channels can be divided into two groups, voltage-gated and ligand-gated channels, depending on the stimulus that triggers the conformational changes leading to channel opening. K+ channels share in common the feature of having high selectivity for K+
Maria L. Garcia +6 more
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