Results 351 to 360 of about 3,016,110 (399)
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KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
Science, 1998The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input.
Hao Wang +7 more
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INWARD RECTIFIER POTASSIUM CHANNELS
Annual Review of Physiology, 1997▪ Abstract The past three years have seen remarkable progress in research on the molecular basis of inward rectification, with significant implications for basic understanding and pharmacological manipulation of cellular excitability. Expression cloning of the first inward rectifier K channel (Kir) genes provided the necessary breakthrough that has ...
Colin G. Nichols, Anatoli N. Lopatin
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Large-conductance Ca²⁺-activated potassium channel in mitochondria of endothelial EA.hy926 cells.
American Journal of Physiology. Heart and Circulatory Physiology, 2013In the present study, we describe the existence of a large-conductance Ca²⁺-activated potassium (BKCa) channel in the mitochondria of the human endothelial cell line EA.hy926. A single-channel current was recorded from endothelial mitoplasts (i.e., inner
P. Bednarczyk +3 more
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Annual Review of Physiology, 2002
▪ Abstract Potassium channels are multi-subunit complexes, often composed of several polytopic membrane proteins and cytosolic proteins. The formation of these oligomeric structures, including both biogenesis and trafficking, is the subject of this review.
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▪ Abstract Potassium channels are multi-subunit complexes, often composed of several polytopic membrane proteins and cytosolic proteins. The formation of these oligomeric structures, including both biogenesis and trafficking, is the subject of this review.
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HERG, a human inward rectifier in the voltage-gated potassium channel family.
Science, 1995In contrast to other members of the Eag family of voltage-gated, outwardly rectifying potassium channels, the human eag-related gene (HERG) has now been shown to encode an inwardly rectifying potassium channel.
M. Trudeau +3 more
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Nature Reviews Neuroscience, 2002
The molecular basis of K+ channel function is universally conserved. K+ channels allow K+ flux and are essential for the generation of electric current across excitable membranes. K+ channels are also the targets of various intracellular control mechanisms, such that the suboptimal regulation of channel function might be related to pathological ...
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The molecular basis of K+ channel function is universally conserved. K+ channels allow K+ flux and are essential for the generation of electric current across excitable membranes. K+ channels are also the targets of various intracellular control mechanisms, such that the suboptimal regulation of channel function might be related to pathological ...
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Pharmacology & Therapeutics, 1990
Many venom toxins interfere with ion channel function. Toxins, as specific, high affinity ligands, have played an important part in purifying and characterizing many ion channel proteins. Our knowledge of potassium ion channel structure is meager because until recently, no specific potassium channel toxins were known, or identified as such. This review
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Many venom toxins interfere with ion channel function. Toxins, as specific, high affinity ligands, have played an important part in purifying and characterizing many ion channel proteins. Our knowledge of potassium ion channel structure is meager because until recently, no specific potassium channel toxins were known, or identified as such. This review
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The Electrophysiology of Potassium Channels
1987Ethanol actions have mainly been described in terms of physicochemical membrane actions. More recently, investigators using intracellular electrophysiological recording techniques have been able to describe ethanol effects on ionic channel function.
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Potassium Channels and Regulation of the Microcirculation [PDF]
Microcirculation, 1998 SUMMARY AND CONCLUSIONS At least three K + channels seem to play an importantrole in the cremasteric microcirculation: K ATP ,K Ca ,and K V channels. Under resting conditions, in vitro and in vivo, only K ATP and K V channels seem to beactive. Calcium-activated K + channels are silentlargely because they require relatively high Ca 2+ concentrations (∼3
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Halothane acts on many potassium channels, including a minimal potassium channel
Neuroscience Letters, 1993There has been considerable controversy over whether general anesthetics act directly on membrane proteins, and if so, whether there are uniquely sensitive protein targets upon which they act. Here, we examine the actions of halothane on a diverse collection of voltage-gated potassium channels expressed in Xenopus oocytes, and find that they are all ...
Vellareddy Anantharam +4 more
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