Results 361 to 370 of about 3,016,110 (399)

A potassium channel mutation in neonatal human epilepsy.

Science, 1998
Benign familial neonatal convulsions (BFNC) is an autosomal dominant epilepsy of infancy, with loci mapped to human chromosomes 20q13.3 and 8q24. By positional cloning, a potassium channel gene (KCNQ2) located on 20q13.3 was isolated and found to be ...
C. Biervert, Björn C. Schroeder, C. Kubisch, S. Berkovic, P. Propping, T. Jentsch, O. Steinlein   +6 more
semanticscholar   +1 more source

Potassium Channels in the Heart

2018
Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function.
openaire   +3 more sources

ATP-Sensitive Potassium Channels

Current Pharmaceutical Design, 2005
ATP-sensitive potassium (K(ATP)) channels link membrane excitability to metabolism. They are regulated by intracellular nucleotides and by other factors including membrane phospholipids, protein kinases and phosphatases. K(ATP) channels comprise octamers of four Kir6 pore-forming subunits associated with four sulphonylurea receptor subunits.
Rodrigo, GC, Standen, NB
openaire   +3 more sources

Potassium Channels

2016
Astrocytes play a critical role in maintaining extracellular K+ homeostasis. Since neuronal activity is accompanied by efflux of K+ from neurons into the extracellular space, tight regulation of extracellular [K+] is critical to avoid hyperexcitability or synaptic dysfunction.
Jacqueline A. Hubbard, Devin K. Binder
openaire   +2 more sources

Peptide toxins and potassium channels

1990
After the first detailed description of the delayed outward potassium current in squid axon by Hodgkin and Huxley (1952) it took electrophysiologists more than 20 years to realize that in addition to it several types of K+ currents can exist in the same cell and that they have a number of functions including modulation of cell excitability and ...
openaire   +3 more sources

Potassium channels and vascular proliferation

General Pharmacology: The Vascular System, 2000
Potassium channels are currently the focus of much attention because of their recently discovered role in the regulation of vascular smooth muscle growth. Dramatic alterations in the expression and activity of K+ channels causing marked changes in the cell's electrical properties accompany enhanced growth of smooth muscle cells (SMCs).
openaire   +4 more sources

Potassium channels and erectile dysfunction

General Pharmacology: The Vascular System, 2002
The incidence of erectile dysfunction (ED), defined as the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance, increases with age and with risk factors for vascular disease, including smoking, diabetes and hypertension.
openaire   +4 more sources

Potassium channels still hot

Trends in Pharmacological Sciences, 1997
The last session of the conference focused on studies which showed the formation of a channel complex consisting of KvLQT1 (a classical K+ channel protein with six transmembrane regions with one pore structure) and another component, termed minK or IsK (a small protein with a single transmembrane domain) resulting in heteromeric channel with new ...
openaire   +3 more sources

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Nature Genetics, 1996
Qing Wang, M. Curran, I. Splawski, T. Burn, J. Millholland, T. VanRaay, J. Shen, K. Timothy, Vincent Gm, Vincent Gm, T. D. Jager, P. Schwartz, J. Towbin, A. Moss, D. Atkinson, G. Landes, T. Connors, M. Keating   +17 more
semanticscholar   +1 more source

Advances in TRP channel drug discovery: from target validation to clinical studies

Nature Reviews Drug Discovery, 2022
Ari-pekka Koivisto, Sandra Duffy, Arpad Szallasi   +2 more
exaly