Results 31 to 40 of about 3,016,110 (399)
Identification of an ATP-sensitive potassium channel in mitochondria
Nature, 2019 Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and their activity must meet cellular energy requirements, but the mechanisms that link organelle performance to ATP levels are poorly understood.
Angela Paggio +8 more
semanticscholar +1 more source
Potassium channels: Novel targets for tumor diagnosis and chemoresistance
Frontiers in Oncology, 2023 In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells.
Meizeng Li +4 more
doaj +1 more source
Epilepsy Gene Therapy Using an Engineered Potassium Channel
Journal of Neuroscience, 2019 Refractory focal epilepsy is a devastating disease for which there is frequently no effective treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way involves irreversible changes to brain tissue, so vector design ...
A. Snowball +12 more
semanticscholar +1 more source
Сardioprotective agents with biaromatic structure. Part 5. Potassium Kv1.5-channels blockers
Фармакокинетика и Фармакодинамика, 2023 The Kv1.5 potassium channel provides an ultra-rapid delayed rectifier potassium current, IKur, that acts selectively in human atrial cells. This makes selective Kv1.5 blockade a promising approach to control atrial arrhythmias without the adverse ...
G. V. Mokrov
doaj +1 more source
Journal of Experimental Botany, 2016 Highlight Overexpression of the potassium channel OsAKT1 improves rice potassium nutrition and resilience to water stress.
I. Ahmad, A. Mian, F. Maathuis
semanticscholar +1 more source
Putative Structural and Functional Coupling of the Mitochondrial BKCa Channel to the Respiratory Chain. [PDF]
PLoS ONE, 2013 Potassium channels have been found in the inner mitochondrial membranes of various cells. These channels regulate the mitochondrial membrane potential, the matrix volume and respiration. The activation of these channels is cytoprotective.
Piotr Bednarczyk +5 more
doaj +1 more source
Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy
Frontiers in Neuroscience, 2023 Developmental and epileptic encephalopathies (DEEs) are severe seizure disorders with inadequate treatment options. Gain- or loss-of-function mutations of neuronal ion channel genes, including potassium channels and voltage-gated sodium channels, are ...
Sophie F. Hill +6 more
doaj +1 more source
A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes [PDF]
, 2005 We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord.
Bahia, PK +7 more
core +1 more source
Potassium channels in articular chondrocytes [PDF]
Channels, 2012 Chondrocytes are the resident cells of cartilage, which synthesize and maintain the extracellular matrix. The range of known potassium channels expressed by these unique cells is continually increasing. Since chondrocytes are non-excitable, and do not need to be repolarized following action potentials, the function of potassium channels in these cells ...
Mobasheri, A +5 more
openaire +4 more sources
Effects of Single Nucleotide Polymorphisms in Human KCNMA1 on BK Current Properties
Frontiers in Molecular Neuroscience, 2019 BK Ca2+-activated K+ channels are important regulators of membrane excitability. Multiple regulatory mechanisms tailor BK current properties across tissues, such as alternative splicing, posttranslational modifications, and auxiliary subunits.
Amber E. Plante +3 more
doaj +1 more source