Results 31 to 40 of about 441,914 (371)
Сardioprotective agents with biaromatic structure. Part 5. Potassium Kv1.5-channels blockers
Фармакокинетика и Фармакодинамика, 2023 The Kv1.5 potassium channel provides an ultra-rapid delayed rectifier potassium current, IKur, that acts selectively in human atrial cells. This makes selective Kv1.5 blockade a promising approach to control atrial arrhythmias without the adverse ...
G. V. Mokrov
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Segment-specific expression of 2P domain potassium channel genes in human nephron. [PDF]
, 2004 BackgroundThe 2P domain potassium (K2P) channels are a recently discovered ion channel superfamily. Structurally, K2P channels are distinguished by the presence of two pore forming loops within one channel subunit. Functionally, they are characterized by
Bockenhauer, Detlef +3 more
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Putative Structural and Functional Coupling of the Mitochondrial BKCa Channel to the Respiratory Chain. [PDF]
PLoS ONE, 2013 Potassium channels have been found in the inner mitochondrial membranes of various cells. These channels regulate the mitochondrial membrane potential, the matrix volume and respiration. The activation of these channels is cytoprotective.
Piotr Bednarczyk +5 more
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Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy
Frontiers in Neuroscience, 2023 Developmental and epileptic encephalopathies (DEEs) are severe seizure disorders with inadequate treatment options. Gain- or loss-of-function mutations of neuronal ion channel genes, including potassium channels and voltage-gated sodium channels, are ...
Sophie F. Hill +6 more
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Potassium channels in articular chondrocytes [PDF]
Channels, 2012 Chondrocytes are the resident cells of cartilage, which synthesize and maintain the extracellular matrix. The range of known potassium channels expressed by these unique cells is continually increasing. Since chondrocytes are non-excitable, and do not need to be repolarized following action potentials, the function of potassium channels in these cells ...
Mobasheri, A +5 more
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Effects of Single Nucleotide Polymorphisms in Human KCNMA1 on BK Current Properties
Frontiers in Molecular Neuroscience, 2019 BK Ca2+-activated K+ channels are important regulators of membrane excitability. Multiple regulatory mechanisms tailor BK current properties across tissues, such as alternative splicing, posttranslational modifications, and auxiliary subunits.
Amber E. Plante +3 more
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Potassium channels as tumour markers [PDF]
FEBS Letters, 2006 An increasing number of ion channels are being found to be causally involved in diseases, giving rise to the new field of “channelopathies”. Cancer is no exception, and several ion channels have been linked to tumour progression. Among them is the potassium channel EAG (Ether‐a‐go‐go).
Stuhmer, Walter +4 more
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Potassium Channels: Complete and Undistorted [PDF]
Current Biology, 2005 The recently determined structure of a mammalian voltage-gated potassium channel has important implications for our understanding of voltage-sensing and gating mechanisms in channels. It is also the first crystal structure of an overexpressed eukaryotic membrane protein.
Grottesi, A, Sands, Z, Sansom, MS
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VKCDB: Voltage-gated potassium channel database
BMC Bioinformatics, 2004 Background The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based component of the membrane potential and are thus central to many critical ...
Gallin Warren J, Li Bin
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A molecular target for viral killer toxin: TOK1 potassium channels. [PDF]
, 1999 Killer strains of S. cerevisiae harbor double-stranded RNA viruses and secrete protein toxins that kill virus-free cells. The K1 killer toxin acts on sensitive yeast cells to perturb potassium homeostasis and cause cell death. Here, the toxin is shown to
Ahmed, A +5 more
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