Potassium channels: Novel targets for tumor diagnosis and chemoresistance
Frontiers in Oncology, 2023 In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells.
Meizeng Li +4 more
doaj +1 more source
Epilepsy Gene Therapy Using an Engineered Potassium Channel
Journal of Neuroscience, 2019 Refractory focal epilepsy is a devastating disease for which there is frequently no effective treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way involves irreversible changes to brain tissue, so vector design ...
A. Snowball +12 more
semanticscholar +1 more source
Сardioprotective agents with biaromatic structure. Part 5. Potassium Kv1.5-channels blockers
Фармакокинетика и Фармакодинамика, 2023 The Kv1.5 potassium channel provides an ultra-rapid delayed rectifier potassium current, IKur, that acts selectively in human atrial cells. This makes selective Kv1.5 blockade a promising approach to control atrial arrhythmias without the adverse ...
G. V. Mokrov
doaj +1 more source
Putative Structural and Functional Coupling of the Mitochondrial BKCa Channel to the Respiratory Chain. [PDF]
PLoS ONE, 2013 Potassium channels have been found in the inner mitochondrial membranes of various cells. These channels regulate the mitochondrial membrane potential, the matrix volume and respiration. The activation of these channels is cytoprotective.
Piotr Bednarczyk +5 more
doaj +1 more source
Journal of Experimental Botany, 2016 Highlight Overexpression of the potassium channel OsAKT1 improves rice potassium nutrition and resilience to water stress.
I. Ahmad, A. Mian, F. Maathuis
semanticscholar +1 more source
A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes [PDF]
, 2005 We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord.
Bahia, PK +7 more
core +1 more source
Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy
Frontiers in Neuroscience, 2023 Developmental and epileptic encephalopathies (DEEs) are severe seizure disorders with inadequate treatment options. Gain- or loss-of-function mutations of neuronal ion channel genes, including potassium channels and voltage-gated sodium channels, are ...
Sophie F. Hill +6 more
doaj +1 more source
Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]
, 2006 KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence ...
AM Evans +23 more
core +3 more sources
Effects of Single Nucleotide Polymorphisms in Human KCNMA1 on BK Current Properties
Frontiers in Molecular Neuroscience, 2019 BK Ca2+-activated K+ channels are important regulators of membrane excitability. Multiple regulatory mechanisms tailor BK current properties across tissues, such as alternative splicing, posttranslational modifications, and auxiliary subunits.
Amber E. Plante +3 more
doaj +1 more source
Fast inactivation in Shaker K+ channels. Properties of ionic and gating currents. [PDF]
, 1998 Fast inactivating Shaker H4 potassium channels and nonconducting pore mutant Shaker H4 W434F channels have been used to correlate the installation and recovery of the fast inactivation of ionic current with changes in the kinetics of gating current known
Bezanilla, F +4 more
core +3 more sources