Results 271 to 280 of about 182,239 (338)

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

Nav1.8 Variant I206M as a Latent Susceptibility Factor in Postaxotomy Ocular Pain. [PDF]

Neurol Genet
Ghovanloo MR, Effraim PR, Tyagi S, Aldrich AM, Yuan JH, Schulman BR, Jacobs DS, Dib-Hajj SD, Waxman SG.   +8 more
europepmc   +1 more source

Crosstalk of KCNH1 and KCNH5 gain-of-function mutations leading to epilepsy and neurodevelopmental disorders. [PDF]

Mol Brain
Bernert A, Rühl P, Schönherr R, Heinemann SH.   +3 more
europepmc   +1 more source

Single-Neuron Critical Intermittency in a Stochastic Hodgkin-Huxley Model. [PDF]

Eur J Neurosci
Varvaras K, Diakonos FK, Kosmidis EK.
europepmc   +1 more source

Modulation of confined water dynamics in ion channels by terahertz electric fields. [PDF]

Nanoscale Adv
Zhao X, Ding W, Wang H, Li Y, Liu C.
europepmc   +1 more source

Towards a unified gating scheme for the CNBD ion channel family. [PDF]

J Gen Physiol
Lin JL, Chanda B.
europepmc   +1 more source

Role of BK channels and Kv4.2 channels in the electrophysiological properties of Merkel cells in rat whisker hair follicles. [PDF]

J Neurophysiol
Yamada A, Gu J.
europepmc   +1 more source

Role of Voltage-gated Potassium Channels in Cancer

The Journal of Membrane Biology, 2005
Ion channels are being associated with a growing number of diseases including cancer. This overview summarizes data on voltage-gated potassium channels (VGKCs) that exhibit oncogenic properties: ether-à-go-go type 1 (Eag1). Normally, Eag1 is expressed almost exclusively in tissue of neural origin, but its ectopic expression leads to uncontrolled ...
L. Pardo, C. Contreras-Jurado, Marta Zientkowska, Frauke Alves, W. Stühmer   +4 more
semanticscholar   +5 more sources

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The voltage-gated potassium channels and their relatives

Nature, 2002
The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they sense changes in voltage or ligand concentration.
G. Yellen
semanticscholar   +3 more sources

Voltage-gated potassium channel antibodies

Neurology, 2016
A radioimmunoassay (RIA) to detect antibodies against what was initially believed to be voltage-gated potassium channels (VGKC) in patients with neuromyotonia was established 20 years ago.1 The rationale for this test came from previous RIA assays that detected antibodies against acetylcholine receptors or voltage-gated calcium channels in which the ...
Francesc, Graus, Mark P, Gorman
openaire   +2 more sources