KCNQs: Ligand- and Voltage-Gated Potassium Channels [PDF]
Frontiers in Physiology, 2020 Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens.
Geoffrey W. Abbott
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Mechanism of electromechanical coupling in voltage-gated potassium channels [PDF]
Frontiers in Pharmacology, 2012 Voltage-gated ion channels play a central role in the generation of action potentials in the nervous system. They are selective for one type of ion – sodium, calcium or potassium. Voltage-gated ion channels are composed of a central pore that allows ions
Rikard eBlunck +3 more
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Voltage-gated potassium channels and genetic epilepsy [PDF]
Frontiers in NeurologyRecent advances in exome and targeted sequencing have significantly improved the aetiological diagnosis of epilepsy, revealing an increasing number of epilepsy-related pathogenic genes.
Yiting Zheng, Jing Chen
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Voltage-Gated Potassium Channels as Regulators of Cell Death [PDF]
Frontiers in Cell and Developmental Biology, 2020 Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane potential, to volume
Magdalena Bachmann +9 more
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Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels [PDF]
PharmaceuticalsBackground/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
Michael T. McCoy +3 more
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Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders [PDF]
Frontiers in Cellular NeuroscienceVoltage-gated potassium channels are a widely distributed subgroup of potassium channels responsible for the efflux of potassium in the repolarisation of the cell membrane, and hence contribute to the latency and propagation of action potentials. As they
Isabel E. Faulkner +4 more
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The role of axonal voltage-gated potassium channels in tDCS
Brain Stimulation, 2022 Background: Transcranial direct current stimulation (tDCS) is a non-invasive sub-threshold stimulation, widely accepted for its amelioration of distinct neuropsychiatric disorders.
Sreerag Othayoth Vasu, Hanoch Kaphzan
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Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels [PDF]
Frontiers in Cellular NeuroscienceVoltage gated potassium channels can be composed of either four identical, or different, pore-forming protein subunits. While the voltage gated channels with identical subunits have been extensively studied both physiologically and mathematically, those ...
Kees McGahan, James Keener
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Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases [PDF]
Frontiers in Cellular NeuroscienceVoltage-gated ion channels are essential for membrane potential maintenance, homeostasis, electrical signal production and controlling the Ca2+ flow through the membrane. Among all ion channels, the key regulators of neuronal excitability are the voltage-
Janire Urrutia +6 more
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Modeling the kinetics of heteromeric potassium channels
Frontiers in Cellular Neuroscience, 2022 Mechanistic mathematical modeling has long been used as a tool for answering questions in cellular physiology. To mathematically describe cellular processes such as cell excitability, volume regulation, neurotransmitter release, and hormone secretion ...
Kees McGahan, James Keener
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