Results 31 to 40 of about 1,785,248 (232)

Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channels [PDF]

, 2003
To understand functions of a single neuron, such as propagation and generation of synaptic or action potentials, a detailed description of the kinetics and distribution of the underlying ionic conductances is essential.
Korngreen, A, Helmstaedter, M., Helmstaedter, Moritz, Schaefer, AT, Korngreen, A., Schaefer, A., Sakmann, Bert, Helmstaedter, M, Sakmann, B, Schaefer, Andreas T., Korngreen, Alon, Sakmann, B., Helmstädter, Moritz   +12 more
core   +1 more source

Role of Voltage-gated Potassium Channels in Cancer

The Journal of Membrane Biology, 2005
Ion channels are being associated with a growing number of diseases including cancer. This overview summarizes data on voltage-gated potassium channels (VGKCs) that exhibit oncogenic properties: ether-à-go-go type 1 (Eag1). Normally, Eag1 is expressed almost exclusively in tissue of neural origin, but its ectopic expression leads to uncontrolled ...
Pardo, L. A., Contreras-Jurado, C., Zientkowska, M., Alves, Frauke, Stühmer, W.   +4 more
openaire   +5 more sources

Contribution of voltage‐gated potassium channels to the regulation of apoptosis [PDF]

FEBS Letters, 2010
Recent evidence points to the crucial involvement of voltage‐gated potassium channels (Kv) in apoptotic volume decrease and in the regulation of apoptosis in several systems. We have recently described the presence of a Kv channel, Kv1.3, in the mitochondria of lymphocytes.
SZABO', ILDIKO', ZORATTI M, GULBINS E.
openaire   +5 more sources

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Christopher M. Fanger, Khoury, Rosana M, Negulescu, Paul A, Cahalan, Michael D, Neben, Amber L, Hubert H. Kerschbaum, Fanger, Christopher M, Rosana M. Khoury, Kerschbaum, Hubert H, Claudia Eder, Amber L. Neben, George R. Ehring, Eder, Claudia, Michael D. Cahalan, Paul A. Negulescu, Ehring, George R, Negulescu, PA, Fanger, CM, Kerschbaum, HH, Khoury, RM, Ehring, GR, Eder, C, Cahalan, MD, Neben, AL   +23 more
core   +1 more source

Potassium channels in prostate and colonic cancer [PDF]

, 2007
Large conductance Ca2+-activated K+ channels in human prostate cancer The KCNMA1 gene encoding the alpha-subunit of BK channels is amplified and BK channel expression is enhanced in late-stage, metastatic and hormone-refractory human prostate cancer ...
Ousingsawat, Jiraporn
core   +1 more source

Behavior of ion channels controlled by electric potential difference and of Toll-type receptors in neuropathic pain pathophysiology

Revista Dor
BACKGROUND AND OBJECTIVES: Neuropathic pain is a severe and refractory medical condition, for which only partially effective treatments are currently available.
André Prato Schmidt, Sérgio Renato Guimarães Schmidt   +1 more
doaj   +1 more source

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. [PDF]

PLoS ONE, 2013
Kv11.1 potassium channels are important for regulation of the normal rhythm of the heartbeat. Reduced activity of Kv11.1 channels causes long QT syndrome type 2, a disorder that increases the risk of cardiac arrhythmias and sudden cardiac arrest.
Chai Ann Ng, Ying Ke, Matthew D Perry, Peter S Tan, Adam P Hill, Jamie I Vandenberg   +5 more
doaj   +1 more source

Voltage-gated Potassium Channels and the Diversity of Electrical Signaling [PDF]

The Journal of Physiology, 2012
Abstract  Since Hodgkin and Huxley discovered the potassium current that underlies the falling phase of action potentials in the squid giant axon, the diversity of voltage‐gated potassium (Kv) channels has been manifested in multiple ways. The large and extended potassium channel family is evolutionarily conserved molecularly and functionally ...
Jan, Lily Yeh, Jan, Yuh Nung
openaire   +4 more sources

The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth [PDF]

, 2009
Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through ...
Feng, J. F., Puja R. Mehta, Sutcliffe, M. J., M. J. Sutcliffe, Mehta, Puja R., Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Feng, J.F., Sutcliffe, M.J., Vavoulis, Dimitris V., Mehta, Puja, R., Vavoulis, D. V., Ashmole, I., Stansfeld, P.J., Feng, Jianfeng, Stansfeld, Phillip J., I. Ashmole, J. F. Feng, P. J. Stansfeld, Vavoulis, D.V., D. V. Vavoulis, P. R. Stanfield, Stanfield, P.R.   +23 more
core   +1 more source

Synthetic ShK-like Peptide from the Jellyfish Nemopilema nomurai Has Human Voltage-Gated Potassium-Channel-Blocking Activity

Marine Drugs
We identified a new human voltage-gated potassium channel blocker, NnK-1, in the jellyfish Nemopilema nomurai based on its genomic information. The gene sequence encoding NnK-1 contains 5408 base pairs, with five introns and six exons.
Ye-Ji Kim, Yejin Jo, Seung Eun Lee, Jungeun Kim, Jae-Pil Choi, Nayoung Lee, Hyokyoung Won, Dong Ho Woo, Seungshic Yum   +8 more
doaj   +1 more source