Results 41 to 50 of about 1,936,199 (178)

Voltage-gated Potassium Channels and the Diversity of Electrical Signaling [PDF]

The Journal of Physiology, 2012
Abstract  Since Hodgkin and Huxley discovered the potassium current that underlies the falling phase of action potentials in the squid giant axon, the diversity of voltage‐gated potassium (Kv) channels has been manifested in multiple ways. The large and extended potassium channel family is evolutionarily conserved molecularly and functionally ...
Jan, Lily Yeh, Jan, Yuh Nung
openaire   +4 more sources

Synthetic ShK-like Peptide from the Jellyfish Nemopilema nomurai Has Human Voltage-Gated Potassium-Channel-Blocking Activity

Marine Drugs
We identified a new human voltage-gated potassium channel blocker, NnK-1, in the jellyfish Nemopilema nomurai based on its genomic information. The gene sequence encoding NnK-1 contains 5408 base pairs, with five introns and six exons.
Ye-Ji Kim, Yejin Jo, Seung Eun Lee, Jungeun Kim, Jae-Pil Choi, Nayoung Lee, Hyokyoung Won, Dong Ho Woo, Seungshic Yum   +8 more
doaj   +1 more source

Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation

Nature Communications, 2020
In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism during voltage-
Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli McFarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui   +14 more
doaj   +1 more source

Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes

Marine Drugs, 2020
Recently, Conorfamide-Sr3 (CNF-Sr3) was isolated from the venom of Conus spurius and was demonstrated to have an inhibitory concentration-dependent effect on the Shaker K+ channel.
Estuardo López-Vera, Luis Martínez-Hernández, Manuel B. Aguilar, Elisa Carrillo, Joanna Gajewiak   +4 more
doaj   +1 more source

Role of Voltage-gated Potassium Channels in Cancer

The Journal of Membrane Biology, 2005
Ion channels are being associated with a growing number of diseases including cancer. This overview summarizes data on voltage-gated potassium channels (VGKCs) that exhibit oncogenic properties: ether-à-go-go type 1 (Eag1). Normally, Eag1 is expressed almost exclusively in tissue of neural origin, but its ectopic expression leads to uncontrolled ...
Pardo, L. A., Contreras-Jurado, C., Zientkowska, M., Alves, Frauke, Stühmer, W.   +4 more
openaire   +5 more sources

Dual Regulation of Voltage-Sensitive Ion Channels by PIP2

Frontiers in Pharmacology, 2012
Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2). Among them are voltage-gated channels, which are crucial
Aldo A Rodríguez Menchaca, Scott K Adney, Lei eZhou, Diomedes E Logothetis   +3 more
doaj   +1 more source

Analysis of a putative voltage‐gated prokaryotic potassium channel [PDF]

European Journal of Biochemistry, 2001
Most of the completely sequenced prokaryotic genomes contain genes of potassium channel homologues, but there is still not much known about the role of these proteins in prokaryotes. Here we describe the large‐scale overproduction and purification of a prokaryotic voltage‐gated potassium channel homologue, Kch, from Escherichia coli.
Ungar, D., Barth, A., Haase, W., Kaunzinger, A., Lewitzki, E., Ruiz, T., Reiländer, H., Michel, H.   +7 more
openaire   +4 more sources

The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1 : contributions of the pore domains [PDF]

, 2007
We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1.
Sutcliffe, M. J., M. J. Sutcliffe, Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Yuill, K. H., Ashmole, I., Yuill, K.H., Stansfeld, P.J., Stansfeld, Phillip J., I. Ashmole, P. J. Stansfeld, K. H. Yuill, P. R. Stanfield, Stanfield, P.R.   +14 more
core   +1 more source

Molecular Studies of Voltage-gated Potassium Channels

Cold Spring Harbor Symposia on Quantitative Biology, 1990
The cloning and characterization of the voltage-activated Shaker potassium channel gene in Drosophila have led to the identification of structural elements involved in potassium channel gating. As found for the voltage-activated sodium channel, the S4 segment, located in the conserved core of the protein, plays a central role in voltage-dependent ...
E, Isacoff, D, Papazian, L, Timpe, Y N, Jan, L Y, Jan   +4 more
openaire   +2 more sources

Predicting the functional effects of voltage-gated potassium channel missense variants with multi-task learning

EBioMedicine, 2022
Summary: Background: Variants in genes encoding voltage-gated potassium channels are associated with a broad spectrum of neurological diseases including epilepsy, ataxia, and intellectual disability.
Christian Malte Boßelmann, Ulrike B.S. Hedrich, Peter Müller, Lukas Sonnenberg, Shridhar Parthasarathy, Ingo Helbig, Holger Lerche, Nico Pfeifer   +7 more
doaj   +1 more source