Results 61 to 70 of about 1,936,199 (178)

Investigations on subunit-specific assembly and structure-function studies of the voltage sensor in KCNQ potassium channels [PDF]

, 2007
A detailed understanding of how potassium channels function is crucial e. g. for the development of drugs, which could lead to novel therapeutic concepts for diseases ranging from diabetes to cardiac abnormalities.
Athanasiadu, Despina, Athanasiadu, D.
core  

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

, 2003
This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels.
McKinnon, D., Wei, A, Rudy, B, Vandenberg, C A, Florian Lesage, Kurachi, Y., Jonathan Robbins, Lesage, Florian, Andreas Karschin, Karschin, A., Wulff, Heike, Robertson, G., Ganetzky, B, Desir, G V, Stuehmer, W, Covarriubias, Manuel, O'Kelly, Ita, Chandy, K., Garcia, M L, Adelman, John P., K. George Chandy, Bayliss, Douglas A., Vandenberg, C., Clapham, D E, Mckinnon, D, Ganetzky, Barry, Nichols, C., Kurachi, Yoshihisa, Carol A. Vandenberg, Yoshihisa Kurachi, O'Kelly, I, Stühmer, W., Gail A. Robertson, Lester, H., Walter Stuehmer, John P. Adelman, Barry Ganetzky, Lazdunski, M, Wymore, R., Covarriubias, M., Garcia, M., Wei, A., O'Kelly, I., Sanguinetti, Michael, Tamkun, M., Aiyar, J, Grissmer, Stephan, Sabina Kuperschmidt, Michael Sanguinetti, Sanguinetti, M., Karschin, Andreas, Karschin, A, Nichols, C G, Chandy, K. George, Vandenberg, Carol A., Michel Lazdunski, S. Wymore, Rudy, B., Seino, S, Randy, Sanguinetti, M, Stuehmer, Walter, Donghee Kim, Robertson, Gail A., Jan, L., Jan, L Y, Adelman, J P, Robbins, J., Lester, Henry A., Furuichi, K., Colin G. Nichols, Wymore, R S, Tamkun, M M, Gutman, G A, Garcia, Maria L., Wei, Aguan, Clapham, D., Lester, H A, Kuperschmidt, S, Tamkun, Michael M., Michael M. Tamkun, Aiyar, Jayashree, Desir, Gary V., Lesage, F, Kurachi, Y, Aguan Wei, Robbins, Jonathan, Jayashree Aiyar, David Mckinnon, Desir, G., Bayliss, D A, Furuichi, Kiyoshi, Kim, D, Stephan Grissmer, Rudy, Bernardo, Kim, D., Kiyoshi Furuichi, Seino, S., Robbins, J, Lazdunski, Michel, Bayliss, D., Wulff, H., Gutman, George A., Wymore, Randy S., Kuperschmidt, Sabina, Jan, Lily Y., Henry A. Lester, Ganetzky, B., Douglas A. Bayliss, Nichols, Colin G., George A. Gutman, Lily Y. Jan, Chandy, K G, Covarriubias, M, Aiyar, J., Gary V. Desir, Maria L. Garcia, Manuel Covarriubias, Lazdunski, M., Seino, Susumu, Bernardo Rudy, Grissmer, S, Furuichi, K, McKinnon, David, Wulff, H, Gutman, G., Kuperschmidt, S., Lesage, F., Kim, Donghee, Grissmer, S., Heike Wulff, Adelman, J., Clapham, David E., David E. Clapham, Susumu Seino, Robertson, G A   +135 more
core   +1 more source

A universal model for spike-frequency adaptation [PDF]

, 2003
Spike-frequency adaptation is a prominent feature of neural dynamics. Among other mechanisms, various ionic currents modulating spike generation cause this type of neural adaptation.
Andreas V. M. Herz, Benda, Jan, Jan Benda, Herz, Andreas V. M.   +3 more
core   +1 more source

Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: The tarantula Chilobrachys jingzhao is one of the largest venomous spiders in China. In previous studies, we purified and characterized at least eight peptides from C. jingzhao venom.
Meichun Deng, Liping Jiang, Xuan Luo, Huai Tao, Songping Liang   +4 more
doaj   +1 more source

Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

Marine Drugs, 2006
Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by
Richard J. Lewis, Graham M. Nicholson
doaj   +1 more source

Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]

, 2013
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E., Hall, Benjamin A., Wallace, Bonnie A., Claire E. Naylor, Christopher W. M. Kay, Paul G. Decaen, Clapham, David, Hall, B.A., Wallace, B. A., DeCaen, P.G., Naylor, Claire E., Benjamin A. Hall, B. A. Wallace, Bagneris, Claire, Kay, C.W.M., DeCaen, Paul, David E. Clapham, Kay, Christopher W. M.   +17 more
core   +2 more sources

Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

Frontiers in Pharmacology, 2012
Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate.
Frank S Choveau, Frank S Choveau, Frank S Choveau, Fayal eAbderemane-Ali, Fayal eAbderemane-Ali, Fayal eAbderemane-Ali, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Zeineb eEs-Salah-Lamoureux, Fabien C Coyan, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Isabelle eBaro, Isabelle eBaro, Isabelle eBaro, Gildas eLoussouarn, Gildas eLoussouarn, Gildas eLoussouarn   +17 more
doaj   +1 more source

Can the Thermodynamic Hodgkin-Huxley Model of Voltage-Dependent Conductance Extrapolate for Temperature? [PDF]

, 2014
Hodgkin and Huxley (H-H) fitted their model of voltage-dependent conductances to experimental data using empirical functions of voltage. The thermodynamic H-H model of voltage dependent conductances is more physically plausible, as it constrains and ...
Michael D. Forrest, Forrest, Michael D., Michael Forrest   +2 more
core   +1 more source

Calcium and Potassium Channels in Experimental Subarachnoid Hemorrhage and Transient Global Ischemia

Stroke Research and Treatment, 2012
Healthy cerebrovascular myocytes express members of several different ion channel families which regulate resting membrane potential, vascular diameter, and vascular tone and are involved in cerebral autoregulation.
Marcel A. Kamp, Maxine Dibué, Toni Schneider, Hans-Jakob Steiger, Daniel Hänggi   +4 more
doaj   +1 more source

Proestrus Differentially Regulates Expression of Ion Channel and Calcium Homeostasis Genes in GnRH Neurons of Mice

Frontiers in Molecular Neuroscience, 2019
In proestrus, the changing gonadal hormone milieu alters the physiological properties of GnRH neurons and contributes to the development of the GnRH surge.
Csaba Vastagh, Norbert Solymosi, Imre Farkas, Zsolt Liposits, Zsolt Liposits   +4 more
doaj   +1 more source