Results 81 to 90 of about 1,936,199 (178)

A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm.

PLoS Computational Biology, 2007
The activity of trans-membrane proteins such as ion channels is the essence of neuronal transmission. The currently most accurate method for determining ion channel kinetic mechanisms is single-channel recording and analysis.
Meron Gurkiewicz, Alon Korngreen
doaj   +1 more source

Inhibition of voltage-gated potassium channels affect expressions of miR-126 and miR-126*in breast cancer cell lines

, 2020
AIM: We aimed to determine the possible correlation between voltage-gated potassium channels and micro RNAs in breast cancer and metastatic breast cancer ...
Oner, C., Cosan, Turgut D., Soyocak, A., TURGUT COŞAN, DİDEM   +3 more
core   +1 more source

Signaling complexes of voltage-gated calcium channels

, 2011
Voltage gated calcium channels are key mediators of depolarization induced calcium entry into electrically excitable cells. There is increasing evidence that voltage gated calcium channels, like many other types of ionic channels, do not operate in ...
Zamponi, Gerald W., Ray W. Turner, Turner, Ray W., Anderson, Dustin M., Dustin Anderson, Gerald W. Zamponi   +5 more
core   +1 more source

Extended secondhand smoke exposure alters potassium channel activity and reduces excitability of cardiac vagal neurons in mice

Frontiers in Physiology
BackgroundDespite the decline in secondhand smoke (SHS) exposure since the implementation of smoking bans in public places, SHS exposure remains a significant health risk factor affecting about 1/3 of non-smokers worldwide.
Junqing Sun, Shiyue Pan, Emma Karey, Kent E. Pinkerton, Chao-Yin Chen   +4 more
doaj   +1 more source

Nicorandil-Induced Hyperkalemia in a Uremic Patient

Case Reports in Medicine, 2012
Nicorandil is an antianginal agent with nitrate-like and ATP-sensitive potassium channel activator properties. After activation of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of ...
Hung-Hao Lee, Po-Chao Hsu, Tsung-Hsien Lin, Wen-Ter Lai, Sheng-Hsiung Sheu   +4 more
doaj   +1 more source

Microbial Voltage-gated Ion Channels

, 2021
Voltage-gated ion channels (VIC) form a superfamily that is well known for transporting potassium, sodium and calcium ions in excitable tissues. Ancestral members of this superfamily were thought to transport only potassium ions, unlike modern homologs ...

core   +1 more source

Peptide Toxins from Marine Conus Snails with Activity on Potassium Channels and/or Currents

Toxins
Toxins from Conus snails are peptides characterized by a great structural and functional diversity. They have a high affinity for a wide range of membrane proteins such as ion channels, neurotransmitter transporters, and G protein-coupled receptors ...
Luis Martínez-Hernández, Estuardo López-Vera, Manuel B. Aguilar   +2 more
doaj   +1 more source

Snake Venom: A Promising Source of Neurotoxins Targeting Voltage-Gated Potassium Channels. [PDF]

Toxins (Basel), 2023
AlShammari AK, Abd El-Aziz TM, Al-Sabi A.   +2 more
europepmc   +1 more source

The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. [PDF]

, 2000
The pharmacology of hSK1, a small conductance calcium-activated potassium channel, was studied in mammalian cell lines (HEK293 and COS-7). In these cell types, hSK1 forms an apamin-sensitive channel with an IC(50) for apamin of 8 nM in HEK293 cells and ...
Shah, M, Haylett, DG
core  

Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels. [PDF]

Function (Oxf), 2023
Kanyo R, Lamothe SM, Urrutia A, Goodchild SJ, Allison WT, Dean R, Kurata HT.   +6 more
europepmc   +1 more source