Results 21 to 30 of about 1,785,248 (232)
Voltage-gated potassium channels as therapeutic targets [PDF]
Nature Reviews Drug Discovery, 2009 The human genome encodes 40 voltage-gated K(+) channels (K(V)), which are involved in diverse physiological processes ranging from repolarization of neuronal and cardiac action potentials, to regulating Ca(2+) signalling and cell volume, to driving cellular proliferation and migration. K(V) channels offer tremendous opportunities for the development of
Wulff, H., Castle, N., Pardo, L.
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Photochromic Blockers of Voltage‐Gated Potassium Channels [PDF]
Angewandte Chemie International Edition, 2009 Photochromic ligands (PCLs) can be optically switchedbetween isomers that show different biological activities. Assuch, they offer an opportunity to convert ligand-actuatedpathways into light-actuated pathways, thus making it possi-ble to control a wide range of biological processes with light.PCLs have been explored for various classes of ...
Matthew R, Banghart +5 more
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Nature Communications, 2017 Dysregulation of voltage gated potassium channels is a feature of neuropathic pain. Here in a rat model the authors identify the microRNA cluster miR-17-92 as a regulator of voltage gated potassium channels in the dorsal root ganglion neurons.
Atsushi Sakai +7 more
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Marine Drugs, 2022 Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior +5 more
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Toxins, 2016 The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez +5 more
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Frontiers in Cellular Neuroscience, 2019 Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 ...
Jakob J. Gutzmann +2 more
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Outward Rectification of Voltage-Gated K+ Channels Evolved at Least Twice in Life History. [PDF]
PLoS ONE, 2015 Voltage-gated potassium (K+) channels are present in all living systems. Despite high structural similarities in the transmembrane domains (TMD), this K+ channel type segregates into at least two main functional categories-hyperpolarization-activated ...
Janin Riedelsberger +2 more
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Kv7 and Kv11 channels in myometrial regulation. [PDF]
, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid +5 more
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Molecular mechanisms of the coupling of gating to voltage sensing in transmembrane proteins [PDF]
, 2014 Voltage gated potassium ion (Kv) channels regulate action potentials of the nervous system by responding to changes in transmembrane voltage, enabling K+ transport across the membrane to restore cells to their resting potential.
Starek, Greg
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Бюллетень сибирской медицины, 2017 The purpose of this work is to study the influence of extracellular ATP (adenosine-3-phosphate), which is an activator of purinergic receptors, on contractive activity of rat aortic ring segments precontracted by α1-adrenoreceptors activation with ...
S. N. Orlov +9 more
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