Results 21 to 30 of about 1,936,199 (178)
KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition [PDF]
, 2011 Voltage-gated potassium (Kv) currents generated by N-type α-subunit homotetramers inactivate rapidly because an N-terminal ball domain blocks the channel pore after activation.
Abbott, G. +10 more
core +1 more source
Kv7 and Kv11 channels in myometrial regulation. [PDF]
, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid +5 more
core +1 more source
Marine Drugs, 2022 Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior +5 more
doaj +1 more source
Oxidative Modulation of Voltage-Gated Potassium Channels [PDF]
Antioxidants & Redox Signaling, 2014 Significance: Voltage-gated K + channels are a large family of K + -selective ion channel protein complexes that open on membrane depolarization. These K +
Nirakar, Sahoo +2 more
openaire +2 more sources
Molecular mechanisms of the coupling of gating to voltage sensing in transmembrane proteins [PDF]
, 2014 Voltage gated potassium ion (Kv) channels regulate action potentials of the nervous system by responding to changes in transmembrane voltage, enabling K+ transport across the membrane to restore cells to their resting potential.
Starek, Greg
core +1 more source
Photochromic Blockers of Voltage‐Gated Potassium Channels [PDF]
Angewandte Chemie International Edition, 2009 Photochromic ligands (PCLs) can be optically switchedbetween isomers that show different biological activities. Assuch, they offer an opportunity to convert ligand-actuatedpathways into light-actuated pathways, thus making it possi-ble to control a wide range of biological processes with light.PCLs have been explored for various classes of ...
Matthew R, Banghart +5 more
openaire +2 more sources
Nature Communications, 2017 Dysregulation of voltage gated potassium channels is a feature of neuropathic pain. Here in a rat model the authors identify the microRNA cluster miR-17-92 as a regulator of voltage gated potassium channels in the dorsal root ganglion neurons.
Atsushi Sakai +7 more
doaj +1 more source
Drug binding sites on Nat1.8 sodium channels [PDF]
, 2008 The voltage-gated sodium channel, Nav 1.8, is known to play an important role in pain signalling. In this thesis, the functional properties and drug binding sites of wild type and mutant Nav 1.8 sodium channel currents were studied in mammalian sensory ...
Browne, Liam Edward
core +5 more sources
Toxins, 2016 The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez +5 more
doaj +1 more source
Voltage-gated potassium channels as therapeutic targets [PDF]
Nature Reviews Drug Discovery, 2009 The human genome encodes 40 voltage-gated K(+) channels (K(V)), which are involved in diverse physiological processes ranging from repolarization of neuronal and cardiac action potentials, to regulating Ca(2+) signalling and cell volume, to driving cellular proliferation and migration. K(V) channels offer tremendous opportunities for the development of
Wulff, H., Castle, N., Pardo, L.
openaire +3 more sources