Results 281 to 290 of about 171,305 (316)
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Voltage-gated potassium channel antibodies
Neurology, 2016A radioimmunoassay (RIA) to detect antibodies against what was initially believed to be voltage-gated potassium channels (VGKC) in patients with neuromyotonia was established 20 years ago.1 The rationale for this test came from previous RIA assays that detected antibodies against acetylcholine receptors or voltage-gated calcium channels in which the ...
Francesc, Graus, Mark P, Gorman
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Voltage-gated Potassium Channel Inhibitors
Current Pharmaceutical Design, 1996Forty years have transpired since tetraethylammonium was first used to selectively inhibit the potassiuin conductance in squid axons. Since then, a large body of work has emerged describing inhibitors of voltage-gated potassium currents in a variety of cells.
W. F. Hopkins +2 more
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Mechanism of Voltage Gating in Potassium Channels
Science, 2012Open and Shut Case Voltage-sensing domains (VSDs) control the activity of voltage-gated ion channels to regulate the ion flow that underlies nerve conduction. Structural and biophysical studies have provided insight into voltage gating; however, understanding has been hindered by the lack of a crystal structure of a fully closed ...
Morten Ø, Jensen +5 more
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Enzymatic activation of voltage-gated potassium channels
Nature, 2006Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference ...
Yajamana, Ramu, Yanping, Xu, Zhe, Lu
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Neuronal trafficking of voltage-gated potassium channels
Molecular and Cellular Neuroscience, 2011The computational ability of CNS neurons depends critically on the specific localization of ion channels in the somatodendritic and axonal membranes. Neuronal dendrites receive synaptic inputs at numerous spines and integrate them in time and space. The integration of synaptic potentials is regulated by voltage-gated potassium (Kv) channels, such as ...
Jensen, Camilla S +2 more
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Voltage-Gated Potassium Channels in Cell Proliferation
Physiology, 2004It is commonly accepted that cells require K+channels to proliferate. The role(s) of K+channels in the process is, however, poorly understood. Cloning of K+channel genes opened the possibility to approach this problem in a way more independent from pharmacological tools.
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Voltage-Gated Potassium Channels: Regulation by Accessory Subunits
The Neuroscientist, 2006Voltage-gated potassium channels regulate cell membrane potential and excitability in neurons and other cell types. A precise control of neuronal action potential patterns underlies the basic functioning of the central and peripheral nervous system. This control relies on the adaptability of potassium channel activities.
Yan Li, S. Um, T. McDonald
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Voltage-gated potassium channels in human ductus arteriosus
The Lancet, 2000We studied tone in the human ductus arteriosus and show that the constriction to oxygen is due to inhibition of voltage-gated potassium channels and, in the acute phase, is independent of endothelin-1.
E, Michelakis +5 more
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Animal Toxins Acting on Voltage-Gated Potassium Channels
Current Pharmaceutical Design, 2008Animal venoms are rich natural sources of bioactive compounds, including peptide toxins acting on the various types of ion channels, i.e. K(+), Na(+), Cl(-) and Ca(2+). Among K+ channel-acting toxins, those selective for voltage-gated K(+) (Kv) channels are widely represented and have been isolated from the venoms of numerous animal species, such as ...
Stéphanie, Mouhat +3 more
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Clinical spectrum of voltage-gated potassium channel autoimmunity
Neurology, 2008To document neurologic, oncologic, and serologic associations of patients in whom voltage-gated potassium channel (VGKC) autoantibodies were detected in the course of serologic evaluation for neuronal, glial, and muscle autoantibodies.Indirect immunofluorescence screening of sera from 130,000 patients performed on a service basis for markers of ...
K M, Tan +4 more
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