Results 221 to 230 of about 193,403 (262)
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Presynaptic potassium channels
Current Opinion in Neurobiology, 1996The past year has witnessed some significant improvements in our understanding of the molecular diversity, subunit composition, and functional properties of K+ channels in heterologous expression systems. Immunocytochemical studies have yielded important information on the localization of K+ channel proteins to synaptic terminals in mammalian brain ...
J, Roeper, O, Pongs
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Nature Reviews Neuroscience, 2002
The molecular basis of K+ channel function is universally conserved. K+ channels allow K+ flux and are essential for the generation of electric current across excitable membranes. K+ channels are also the targets of various intracellular control mechanisms, such that the suboptimal regulation of channel function might be related to pathological ...
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The molecular basis of K+ channel function is universally conserved. K+ channels allow K+ flux and are essential for the generation of electric current across excitable membranes. K+ channels are also the targets of various intracellular control mechanisms, such that the suboptimal regulation of channel function might be related to pathological ...
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Potassium channels in the vasculature
Current Opinion in Nephrology and Hypertension, 1998Many important cellular functions are regulated by vascular potassium channels, including the resting membrane potential. Recent evidence suggests that the function of these channels is altered in pathophysiological disorders of the cardiovascular system.
L H, Clapp, A, Tinker
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INWARD RECTIFIER POTASSIUM CHANNELS
Annual Review of Physiology, 1997▪ Abstract The past three years have seen remarkable progress in research on the molecular basis of inward rectification, with significant implications for basic understanding and pharmacological manipulation of cellular excitability. Expression cloning of the first inward rectifier K channel (Kir) genes provided the necessary breakthrough that has ...
C G, Nichols, A N, Lopatin
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The Electrophysiology of Potassium Channels
1987Ethanol actions have mainly been described in terms of physicochemical membrane actions. More recently, investigators using intracellular electrophysiological recording techniques have been able to describe ethanol effects on ionic channel function.
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Annual Review of Physiology, 2002
▪ Abstract Potassium channels are multi-subunit complexes, often composed of several polytopic membrane proteins and cytosolic proteins. The formation of these oligomeric structures, including both biogenesis and trafficking, is the subject of this review.
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▪ Abstract Potassium channels are multi-subunit complexes, often composed of several polytopic membrane proteins and cytosolic proteins. The formation of these oligomeric structures, including both biogenesis and trafficking, is the subject of this review.
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Pharmacology & Therapeutics, 1990
Many venom toxins interfere with ion channel function. Toxins, as specific, high affinity ligands, have played an important part in purifying and characterizing many ion channel proteins. Our knowledge of potassium ion channel structure is meager because until recently, no specific potassium channel toxins were known, or identified as such. This review
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Many venom toxins interfere with ion channel function. Toxins, as specific, high affinity ligands, have played an important part in purifying and characterizing many ion channel proteins. Our knowledge of potassium ion channel structure is meager because until recently, no specific potassium channel toxins were known, or identified as such. This review
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Halothane acts on many potassium channels, including a minimal potassium channel
Neuroscience Letters, 1993There has been considerable controversy over whether general anesthetics act directly on membrane proteins, and if so, whether there are uniquely sensitive protein targets upon which they act. Here, we examine the actions of halothane on a diverse collection of voltage-gated potassium channels expressed in Xenopus oocytes, and find that they are all ...
L, Zorn +4 more
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Peptide toxins and potassium channels
1990After the first detailed description of the delayed outward potassium current in squid axon by Hodgkin and Huxley (1952) it took electrophysiologists more than 20 years to realize that in addition to it several types of K+ currents can exist in the same cell and that they have a number of functions including modulation of cell excitability and ...
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PERMEATION IN POTASSIUM CHANNELS: Implications for Channel Structure
Annual Review of Biophysics and Biophysical Chemistry, 1987The SR K+ channel is a single-ion channel with a tunnel that is not very selective, while the DR and CaK channels are both more selective, multi-ion channels. The permeation mechanisms of the three channels are probably most systematically distinguished by the length of their tunnels; the SR has the shortest and the DR the longest.
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