Results 241 to 250 of about 355,939 (300)

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

Advanced Science, EarlyView.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou, Théo Gauvrit, Célien Vandromme, Alexandre Cornier, Anna Saint‐Jean, Yves Le Feuvre, Melanie Ginger, Andreas Frick   +7 more
wiley   +1 more source

The roles of melatonin and potassium channels in relaxation response to ang 1-7 in diabetic rat isolated aorta. [PDF]

Cytotechnology
Mahmood NMS, Mahmood AMR, Maulood IM.
europepmc   +1 more source

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Slick potassium channels limit TRPM3-mediated activation of sensory neurons. [PDF]

Front Pharmacol
Engel P, Zhou F, Tran BTT, Schmidtko A, Lu R.   +4 more
europepmc   +1 more source

Binding kinetics of quaternary ammonium ions in Kcv potassium channels. [PDF]

Channels (Austin)
Korn T, Hansen UP, Gabriel TS, Rauh O, Drexler N, Schroeder I.   +5 more
europepmc   +1 more source

From Atrial Small-conductance Calcium-activated Potassium Channels to New Antiarrhythmics. [PDF]

Eur Cardiol
Saljic A, Heijman J, Dobrev D.
europepmc   +1 more source

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep. [PDF]

Proc Natl Acad Sci U S A
Constantino NJ, Carroll CM, Williams HC, Vekaria HJ, Yuede CM, Saito K, Sheehan PW, Snipes JA, Raichle ME, Musiek ES, Sullivan PG, Morganti JM, Johnson LA, Macauley SL.   +13 more
europepmc   +1 more source

The Shab family potassium channels are highly enriched at the presynaptic terminals of human neurons. [PDF]

J Biol Chem
Benner O, Karr CH, Quintero-Gonzalez A, Tamkun MM, Chanda S.   +4 more
europepmc   +1 more source

Corrigendum to 'Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice' (Br J Anaesth 2020; 125: 298-307). [PDF]

Br J Anaesth
Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M.   +13 more
europepmc   +1 more source