Results 1 to 10 of about 997,205 (406)
Advanced Materials, 2023 The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic lipid component. LNP mRNA systems composed of optimized ionizable lipids often display distinctive mRNA‐rich “bleb” structures.
Pieter Cullis
exaly +2 more sources
Single-cell entropy for accurate estimation of differentiation potency from a cell’s transcriptome
Nature Communications, 2017 The ability to quantify differentiation potential of single cells is a task of critical importance. Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation potency of a single cell can be approximated by computing the ...
Andrew E Teschendorff
exaly +2 more sources
Antibacterial Potency of Honey
International Journal of Microbiology, 2019 Despite the developments in controlling infectious disease around the world, they are still the second biggest cause of morbidity and mortality due in part to the increase in drug resistance among large numbers of the bacterial strains. This means that new strategies are needed to prevent and treat infectious disease.
N. Albaridi
openaire +4 more sources
Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost
Nature, 2022 The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals1–3. Despite the reduced protection from infection, individuals who received three doses of an mRNA vaccine were highly protected from more serious consequences of ...
F. Muecksch +24 more
semanticscholar +1 more source
Preparation and the assessed efficacy of oral baits for the vaccination of free-roaming dogs against rabies [PDF]
Veterinary World, 2022 Background and Aim: Rabies is considered a highly fatal zoonotic disease and many deaths in humans have been associated with dog bites. This study was designed to prepare an oral anti-rabies vaccine in the form of baits to eliminate the disease in free ...
Naglaa I. Aly +7 more
doaj +1 more source
New Modified Recombinant Botulinum Neurotoxin Type F with Enhanced Potency
Toxins, 2021 Botulinum neurotoxins (BoNTs) are notorious toxins and powerful agents and can be lethal, causing botulism, but they are also widely used as therapeutics, particularly to treat neuromuscular disorders.
David Burgin +9 more
doaj +1 more source
Toxins, 2021 The safe and effective dosing of botulinum neurotoxins (BoNTs) requires accurate and reliable methods to measure their potency. Several novel methods have been introduced over the past decade; however, only few studies have compared the potency of BoNT ...
Ji-Yeon Hong +4 more
doaj +1 more source
Journal of Computer-Aided Molecular Design, 2020 Difficulties in interpreting machine learning (ML) models and their predictions limit the practical applicability of and confidence in ML in pharmaceutical research.
Raquel Rodríguez-Pérez, J. Bajorath
semanticscholar +1 more source
Actions of Agonists, Fipronil and Ivermectin on the Predominant In Vivo Splice and Edit Variant (RDLbd, I/V) of the Drosophila GABA Receptor Expressed in Xenopus laevis Oocytes [PDF]
, 2014 Ionotropic GABA receptors are the targets for several classes of insecticides. One of the most widely-studied insect GABA receptors is RDL (resistance to dieldrin), originally isolated from Drosophila melanogaster.
Biggin, P +5 more
core +7 more sources