Results 11 to 20 of about 514,099 (251)

Development and Characterization of an In Vitro Cell-Based Assay to Predict Potency of mRNA–LNP-Based Vaccines

open access: yesVaccines, 2023
Messenger RNA (mRNA) vaccines have emerged as a flexible platform for vaccine development. The evolution of lipid nanoparticles as effective delivery vehicles for modified mRNA encoding vaccine antigens was demonstrated by the response to the COVID-19 ...
Nisarg Patel
exaly   +3 more sources

‘Shell to Sea’ in Ireland: building social movement potency [PDF]

open access: yes, 2008
In 1996 the Corrib gas field, holding over 1 trillion cubic feet of gas, was discovered by Enterprise Oil 83km off the North West coast of Ireland.
Sullivan, Sian, Salter, K.
core   +8 more sources

Inhibitors of PD-1 in Non-Small Cell Lung Cancer: A Meta-Analysis of Clinical and Molecular Features

open access: yesFrontiers in Immunology, 2022
ObjectivePD-1 inhibitors have become an indispensable treatment in Non-Small Cell Lung Cancer (NSCLC), but the potential predictive value of clinical and molecular features need to be clarified. The objective of the study was to study the potency of PD-1
Gengwei Huo   +3 more
doaj   +1 more source

Ius sive potentia: Paul and Spinoza [PDF]

open access: yesFilozofija i Društvo, 2020
This article is a part of a research project entitled Law as Potency, that, broadly put, investigates the relation between law and ontology. I argue, starting from St. Paul, that an ontological perspective can be understood as the possibility of
Milović Miroslav
doaj   +1 more source

Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor [PDF]

open access: yes, 2023
Akuammine (1) and pseudo-akuammigine (2) are indole alkaloids found in the seeds of the akuamma tree (Picralima nitida). Both alkaloids are weak agonists of the mu opioid receptor (µOR); however, they produce minimal effects in animal models of ...
Kevin, Appourchaux   +11 more
core   +2 more sources

Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas

open access: yesFrontiers in Pharmacology, 2021
Quality control has been a significant issue in herbal medicine since herbs became widely used to heal. Modern technologies have improved the methods of evaluating the quality of medicinal herbs but the methods of adulterating them have also grown in ...
Steven B. Woodley   +7 more
doaj   +1 more source

A Quantum-Mechanical Approach to Predicting Carcinogenic Potency of N-nitrosamine Impurities in Pharmaceuticals [PDF]

open access: yes, 2022
N-nitrosamine contaminants in medicinal products are of concern due to their high carcinogenic potency; however, not all nitrosamines are created equal, and some are relatively benign chemicals.
Adelina, Voutchkova-Kostal   +1 more
core   +2 more sources

Interchangeability of the Assays Used to Assess the Activity of Anti-SARS-CoV-2 Monoclonal Antibodies

open access: yesViruses, 2023
The recent global COVID-19 pandemic caused by SARS-CoV-2 lasted for over three years. A key measure in combatting this pandemic involved the measurement of the monoclonal antibody (mAb)-mediated inhibition of binding between the spike receptor-binding ...
Brady T. Hickerson   +5 more
doaj   +1 more source

Lamivudine versus Entecavir for Newly Diagnosed Hepatitis B Virus-Related Hepatocellular Carcinoma

open access: yesGut and Liver, 2016
Background/AimsAntiviral therapy is a key component in the management of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. However, whether the potent drug entecavir is more effective than a less potent drug, such as lamivudine, in
Jung Hee Kim   +9 more
doaj   +1 more source

Efficacy of Atezolizumab for Advanced Non-Small Cell Lung Cancer Based on Clinical and Molecular Features: A Meta-Analysis

open access: yesFrontiers in Immunology, 2022
ObjectiveAtezolizumab is becoming a significant therapy for non-small cell lung cancer (NSCLC), but its efficacy needs to be further improved. The aims of this study are to clarify the potency of atezolizumab-based therapy in advanced NSCLC patients with
Wenjie Liu   +3 more
doaj   +1 more source

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