Results 21 to 30 of about 514,099 (251)

The Evolving Landscape of Potency Assays

, 2023
There is a "goldilocks" aspect to potency assays. On the one hand, a comprehensive evaluation of the cell product with detailed quantitative measurement of the critical quality attribute/s of the desired biological activity is required. On the other hand,
Burns J. S.
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A potency of life [PDF]

, 2016
A potency of ...
Catherine Gill (1256124), Matthew Inglis (433623), Catherine M. Armstrong (7148579), Gillian Whiteley (1383738)   +3 more
core   +7 more sources

Analogs of 6-Bromohypaphorine with Increased Agonist Potency for α7 Nicotinic Receptor as Anti-Inflammatory Analgesic Agents

Marine Drugs, 2023
Hypaphorines, tryptophan derivatives, have anti-inflammatory activity, but their mechanism of action was largely unknown. Marine alkaloid L-6-bromohypaphorine with EC50 of 80 μM acts as an agonist of α7 nicotinic acetylcholine receptor (nAChR) involved ...
Igor A. Ivanov, Andrei E. Siniavin, Victor A. Palikov, Dmitry A. Senko, Irina V. Shelukhina, Lyubov A. Epifanova, Lucy O. Ojomoko, Svetlana Y. Belukhina, Nikita A. Prokopev, Mariia A. Landau, Yulia A. Palikova, Vitaly A. Kazakov, Natalia A. Borozdina, Arina V. Bervinova, Igor A. Dyachenko, Igor E. Kasheverov, Victor I. Tsetlin, Denis S. Kudryavtsev   +17 more
doaj   +1 more source

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids [PDF]

, 2014
The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted ...
Lister, Adam, Shelton, Luke M., Kratschmar, Denise V., Copple, Ian M., Park, B. Kevin, Goldring, Christopher E., Honda, Tadashi, Odermatt, Alex, Walsh, Joanne, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T.   +10 more
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Quality Control of Quantitative High Throughput Screening Data

Frontiers in Genetics, 2019
Quantitative high throughput screening (qHTS) experiments can generate 1000s of concentration-response profiles to screen compounds for potentially adverse effects.
Keith R. Shockley, Shuva Gupta, Shawn F. Harris, Soumendra N. Lahiri, Shyamal D. Peddada   +4 more
doaj   +1 more source

In vitro Comparison of the Intrinsic Activity of Functional Antagonism between β-agonists and Spasmogens in the Guinea-pig Tracheal Muscle

Allergology International, 2005
Background: The bronchodilating action of β-agonists depends on the tone of airway smooth muscle or on spasmogen. To estimate the precise intrinsic activity of β-agonists, relaxation responses should be examined on maximally contracted airway smooth ...
Yuichiro Kamikawa, Naomi Takayama
doaj   +1 more source

FACE: the barefaced facts of AI potency [PDF]

, 2010
Alain MonnierInstitut Régional Fédératif du Cancer (IFRC), Centre Hospitalier Belfort-Montbéliard, Montbeliard Cedex, FranceAbstract: The use of third-generation aromatase inhibitors (AIs), such as anastrozole ...
Alain Monnier
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Bovine Mucosal Heparins Are Comparable to Porcine Mucosal Heparin at USP Potency Adjusted Levels

Frontiers in Medicine, 2019
Introduction: Bovine mucosal heparins (BMH) are currently being developed for re-introduction for both medical and surgical indications. BMH active pharmaceutical ingredient (API) exhibits a somewhat weaker USP potency when compared to PMHs.
Walter Jeske, Ahmed Kouta, Ambar Farooqui, Fakiha Siddiqui, Varun Rangnekar, Manoj Niverthi, Rajan Laddu, Debra Hoppensteadt, Omer Iqbal, Jeanine Walenga, Jawed Fareed   +10 more
doaj   +1 more source

Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels

Frontiers in Physiology, 2023
Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the treatment of epilepsy.
Carol J. Milligan, Lyndsey L. Anderson, Lyndsey L. Anderson, Lyndsey L. Anderson, Iain S. McGregor, Iain S. McGregor, Iain S. McGregor, Jonathon C. Arnold, Jonathon C. Arnold, Jonathon C. Arnold, Steven Petrou, Steven Petrou   +11 more
doaj   +1 more source

The antibacterial potency of the medicinal maggot, Lucilia sericata (Meigen): Variation in laboratory evaluation [PDF]

, 2010
Research to quantify the potency of larval excretion/secretion from Lucilia sericata using liquid culture assays has produced contradictory results. In this study, viable counting was used to investigate the effectiveness of excretion/secretion against ...
Dixon, Ron A., Dorothy E. Gennard, Ronald A. Dixon, Barnes, Kate M., Katherine M. Barnes, Gennard, Dorothy E.   +5 more
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