Results 21 to 30 of about 380,673 (266)
Isolation and Characterization of the Novel Botulinum Neurotoxin A Subtype 6
mSphere, 2018 Botulinum neurotoxins (BoNTs), the most potent toxins known to humans and the causative agent of botulism, exert their effect by entering motor neurons and cleaving and inactivating SNARE proteins, which are essential for neurotransmitter release.
Molly S. Moritz +4 more
doaj +1 more source
Emergent Penile Venous Stripping for Treating Adolescent Impotence
LifeIntroduction: Traditional anatomy-based penile venous surgery is deemed inadequate. Based on revolutionary insights into penile vasculature, penile venous stripping (PVS) shows promise in treating adolescent erectile dysfunction (AED). We aimed to report
Ko-Shih Chang +4 more
doaj +1 more source
LifeIntroduction: Herein, we explore whether coil embolization (CE) is effective in treating veno-occlusive dysfunction (VOD). We present five cases with seven CE episodes and a narrative literature review.
Ko-Shih Chang +5 more
doaj +1 more source
Finding the potency in planarians
Communications Biology, 2022 Planarian flatworms are well-known for their regenerative ability, which is dependent on a large population of adult stem cells, called neoblasts, at least some of which are pluripotent. Here, two recent studies are compared that have begun to address this fundamental question of whether all or only some neoblasts are pluripotent.
openaire +3 more sources
Frontiers in Public HealthBackgroundThe prevalence of cannabis as the most commonly used illicit substance in the United States and around the globe is well-documented. Studies have highlighted a noticeable uptrend in the potency of cannabis in the United states.
Mahmoud A. ElSohly +4 more
doaj +1 more source
Biomarker Signatures of Quality for Engineering Nasal Chondrocyte-Derived Cartilage
Frontiers in Bioengineering and Biotechnology, 2020 The definition of quality controls for cell therapy and engineered product manufacturing processes is critical for safe, effective, and standardized clinical implementation.
M. Adelaide Asnaghi +7 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille +9 more
wiley +1 more source
Inhibitors of PD-1 in Non-Small Cell Lung Cancer: A Meta-Analysis of Clinical and Molecular Features
Frontiers in Immunology, 2022 ObjectivePD-1 inhibitors have become an indispensable treatment in Non-Small Cell Lung Cancer (NSCLC), but the potential predictive value of clinical and molecular features need to be clarified. The objective of the study was to study the potency of PD-1
Gengwei Huo +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger +7 more
wiley +1 more source