Results 91 to 100 of about 997,205 (406)

Olfactory sensitivity of the marine flatfish Solea senegalensis to conspecific body fluids [PDF]

, 2017
Chemical communication is better understood in freshwater fish than marine fish. The Senegalese sole (Solea senegalensis) is a marine flatfish wherein one of the problems in aquaculture is the poor reproductive performance of hatchery-bred males.
Aeschlimann, Agulleiro, Appelt, Barata, Baynes, Belanger, Buchinger, Carazo, Carazo, Cardwell, Chauvigné, Chauvigné, Chauvigné, Churcher, Colombo, Dinis, Diogo, Doldán, Dulka, Elofsson, Emanuel, Fatsini, Fletcher, Ghosal, Guzmán, Hubbard, Hubbard, Hubbard, Huertas, Huertas, Kasumyan, Keller-Costa, Kitamura, Li, Marshall, Martín, Mañanós, Milinski, Milinski, Miranda, Olsén, Prasada Rao, Rosengrave, Silver, Sorensen, Sorensen, Stacey, Stacey, Velez, Velez, Velez, Velez, Velez, Wyatt, Yabuki, Yambe   +55 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Spectrophotometric analysis of thrombolytic activity: SATA assay [PDF]

, 2017
Introduction: Measurement of thrombolytic activity i.e. clot lysis is crucial for research and development of novel thrombolytics. It is also a key factor in assessment of the effectiveness of conventionally used thrombolytic agents in the clinic, which ...
Entekhabi, Nazila, Eskandani, Morteza, Farhoudi, Mehdi, Mohammadian, Reza, Rafi, Mohammad, Zamanlu, Masumeh   +5 more
core   +2 more sources

Vaccine blunts fentanyl potency in male rhesus monkeys

Neuropharmacology, 2019
One proposed factor contributing to the increased opioid overdose deaths is the increased frequency of synthetic opioids, including fentanyl and fentanyl analogs.
Rebekah D. Tenney, Steven Blake, Paul T. Bremer, Bin Zhou, Candy S. Hwang, J. Poklis, K. Janda, M. Banks   +7 more
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Development of 6-amido-4-aminoisoindolyn-1,3-diones as p70S6K1 inhibitors and potential breast cancer therapeutics

Frontiers in Molecular Biosciences
IntroductionMany breast cancer therapeutics target the PI3K/AKT/mTOR oncogenic pathway. Development of resistance to the therapeutics targeting this pathway is a frequent occurrence.
Adrian Thornton, Rajesh Komati, Hogyoung Kim, Jamiah Myers, Kymmia Petty, Rion Sam, Elijah Johnson-Henderson, Keshunna Reese, Linh Tran, Vaniyambadi Sridhar, Christopher Williams, Jayalakshmi Sridhar   +11 more
doaj   +1 more source

Potential bronchoconstrictor stimuli in acid fog. [PDF]

, 1989
Acid fog is complex and contains multiple stimuli that may be capable of inducing bronchoconstriction. These stimuli include sulfuric and niric acids, the principal inorganic acids present; sulfites, formed in the atmosphere as a reaction product of ...
Balmes, JR, Fine, JM, Gordon, T, Sheppard, D   +3 more
core   +2 more sources

Photohemolytic Potency of Tetracyclines

Journal of Investigative Dermatology, 1985
Hemolysis induced by long-wave ultraviolet radiation (UVA) and 8 different commercial tetracycline derivatives was studied in a model using human red blood cells. Demethylchlortetracycline and doxycycline were shown to have pronounced hemolytic properties causing 88% and 85% hemolysis, respectively, at a concentration of 50 micrograms/ml and 72 J/cm2 ...
Bjellerup, Mats, Ljunggren, B.o.
openaire   +2 more sources

Fine-tuning the CAR spacer improves T-cell potency

Oncoimmunology, 2016
The adoptive transfer of genetically engineered T cells expressing chimeric antigen receptors (CARs) has emerged as a transformative cancer therapy with curative potential, precipitating a wave of preclinical and clinical studies in academic centers and ...
N. Watanabe, P. Bajgain, S. Sukumaran, Salma Ansari, H. Heslop, C. Rooney, M. Brenner, A. Leen, J. Vera   +8 more
semanticscholar   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source