Results 141 to 150 of about 1,009,444 (403)

Defining criteria for broadly neutralizing HIV antibodies

open access: yesFrontiers in Immunology
Over the course of a few years, a small percentage of individuals with HIV-1 develop broadly neutralizing antibodies (bnAbs) capable of neutralizing diverse viruses.
Elizabeth-Sharon David-Fung   +5 more
doaj   +1 more source

Hyaluronic acid alters vessel behavior in CXCL12-treated HUVECs [PDF]

open access: yes, 2018
Hyaluronic acid (HA) is a key component of the extracellular matrix known for absorbing water, swelling, and altering solid stress of tumors. HA’s anionic behavior may provide important biochemical effects toward tumor progression as well.
Seibel, Alex J.
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Long-term stability of clinical-grade lentiviral vectors for cell therapy

open access: yesMolecular Therapy: Methods & Clinical Development
The use of lentiviral vectors in cell and gene therapy is steadily increasing, both in commercial and investigational therapies. Although existing data increasingly support the usefulness and safety of clinical-grade lentiviral vectors used in cell ...
Julie K. Jadlowsky   +18 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

POTENCY AND DEVELOPMENT STRATEGY OF SPOTTED BUFFALO IN SANGGALANGI SUBDISTRICT, NORTH TORAJA DISTRICT, SOUTH SULAWESI [PDF]

open access: yesJournal of the Indonesian Tropical Animal Agriculture, 2012
The aim of this research was to analyze the reproduction performances, potency and development strategy of Torajans spotted buffalo. This research was done from July to September 2010 in Sanggalangi subdistrict, North Toraja district, South Sulawesi ...
D. J. Setyono, A. Afandi, Komariah
doaj  

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

Management of erectile dysfunction in patients who failed prior vascular intervention

open access: yesUrological Science, 2015
Cheng-Hsing Hsieh   +3 more
doaj   +1 more source

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