Results 211 to 220 of about 583,846 (360)

Engineering multispecific antibodies with complete killing selectivity through the closed-loop integration of machine learning and high-throughput experimentation. [PDF]

MAbs
Grace J, Colin PY, Foxler D, Haynes W, Howsham C, Kassimatis L, Mavrogonatou L, Mighell R, McClory J, Mullin M, Ogola T, Townsend A, Ravi S, Wossnig L, van Heeke G.   +14 more
europepmc   +1 more source

Inducible HIV-1 Reservoir Reduction Assay (HIVRRA), a Fast and Sensitive Assay to Test Cytotoxicity and Potency of Cure Strategies to Reduce the Replication-Competent HIV-1 Reservoir in Ex Vivo PBMCs

Jade Jansen, Teunis B. H. Geijtenbeek, Neeltje A. Kootstra   +2 more
openalex   +1 more source

Deep learning vs classical methods in potency & ADME prediction: Insights from the Polaris Antiviral Challenge [PDF]

Yvan Fischer, Dhoha Triki, Ruel Cedeno
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Comparison of Ultrapreservation and Retzius-Sparing Techniques in Robotic Radical Prostatectomy: Single-Center Experience. [PDF]

Medicina (Kaunas)
Beyatlı M, Güngör HS, Haberal HB, İnkaya A, Sobay R, Tahra A, Küçük EV.   +6 more
europepmc   +1 more source

Effect of Different Potencies of Nanomedicine Aconitum Napelles on Its Spectral and Antibacterial Properties

, 2015
Subhajit Ghosh Subhajit Ghosh
openalex   +1 more source

The Effect of Ethanol Extract of Cogon Grass Root (Imperata cylindrica L.) to Fatty Acid Binding Protein 4 and oxidative stress correlated factors in Sepsis Mice ModelThe Potency of Moringa oleifera as Protective Agent to Cardiac Damage and Vascular Dysfunction Extended Data

, 2021
Mirasari Putri, Raden Aliya T. M. Djajanagara, Ghaliby Ardhia Ramli, Neni Anggraeni, Nugraha Sutadipura, Nur Atik, Mas Rizky A. A. Syamsunarno   +6 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection. [PDF]

Nat Commun
Yanagidaira M, Nagata T, Hasegawa J, Ishii T, Ebihara S, Nawa M, Yokota T.   +6 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source