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Anti-cancer effects and mechanism of actions of aspirin analogues in the treatment of glioma cancer [PDF]
, 2012 INTRODUCTION: In the past 25 years only modest advancements in glioma treatment have been made, with patient prognosis and median survival time following diagnosis only increasing from 3 to 7 months.A. A. Hill, A. Altinkaya, A. Baborie, A. Bahl, A. Brodbelt, A. Brodbelt, A. Brodbelt, A. Brodbelt, A. Chalmers, A. Dubocq, A. Eason, A. Elmahdi, A. Frary, A. Frary, A. Gerhard, A. Gullan, A. Hajitou, A. J. Frary, A. Jackson, A. James, A. James, A. Joannides, A. Kia, A. Niranjan, A. O'Brien, A. Shaw, A. Shenoy, A. Shivane, A. Shoakazemi, A. Singh, A. Singleton, A. Sofat, A. Sottoriva, A. Williamson, A. Young, A. Young, B. Hacking, B. Harding, B. Haylock, B. Haylock, B. Haylock, B. Herron, C. Chatelain, C. Crosby, C. Davis, C. Hanemann, C. L. Nigro, C. Lawrence, C. O. Hanemann, C. Romanowski, C. Schmidberger, C. Walker, C. Walker, C. Walker, C. Watts, C. Watts, C. Watts, D. A. Jellinek, D. Bowyer, D. Cavers, D. Conkey, D. Coope, D. Crooks, D. Crooks, D. Crooks, D. du Plessis, D. Elder, D. G. O'Donovan, D. Husband, D. J. Coope, D. Kondziolka, D. Parkinson, D. Sheer, D. Thompson, D. W. Ellison, E. A. Chiocca, E. Clarke, E. Ercolano, E. Goessl, E. Hatzimichael, E. Healy, E. McGrath, E. Murray, F. Harris, F. McKevitt, F. Roncaroli, F. Roncaroli, F. Rowther, F. Rowther, F. Rowther, F. Turkheimer, G. Cruickshank, G. Hall, G. Hall, G. J. Pilkington, G. J. Pilkington, G. Pilkington, G. Pilkington, G. Pilkington, G. Pilkington, G. Thompson, G. Wall, G. Zilidis, H. Coley, H. Dogra, H. Kano, H. Kardooni, H. Wong, I. C. Morley, I. Corbett, I. Craven, I. Nicholl, I. Noorani, I. Qaddoumi, I. R. Whittle, I. Spiteri, J. Alder, J. Baily, J. Bambrough, J. Bambrough, J. Bomalaski, J. Darling, J. Darling, J. Darling, J. Darling, J. Darling, J. Dunn, J. Dunn, J. Harney, J. Holliday, J. Ironside, J. Larsen, J. Leggate, J. Logan, J. M. Przystal, J. N. Jeyapalan, J. Simpson, J. Singh, J. Tavare, K. Ashkan, K. Ashkan, K. Ashton, K. Ashton, K. Ashton, K. Chen, K. Das, K. E. Hatherell, K. Herholz, K. Hopkins, K. Hopkins, K. Janczar, K. Karabatsou, K. Karabatsou, K. Karakoula, K. Karakoula, K. Kroese, K. M. Kurian, K. M. Kurian, K. M. Kurian, K. M. Prise, K. McCarthy, K. O'Neil, K. Phipps, K. Prise, L. Brazil, L. Donovan, L. Evans, L. Lattanzio, L. Lunsford, L. Mohsen, L. Rada, L. Shaw, L. Spinelli, L. Steele, L. Taggart, L. Wallace, L. Zhou, M. A. Mumin, M. Altinkaya, M. Anand, M. Anand, M. Arora, M. Barczyk, M. Boissinot, M. Bradley, M. C. Schmid, M. Diaz, M. Donnelly, M. Frame, M. Jenkinson, M. Jenkinson, M. Jenkinson, M. Keeling, M. Mackinnon, M. McLean, M. Morris, M. R. Morris, M. Williams, N. A. Pullen, N. A. Pullen, N. Burnet, N. Cohen, N. D. Mazarakis, N. Hoggard, N. Marko, N. Nianiaris, N. Potter, N. R. Leslie, N. Rathi, N. Rathi, N. Syed, O. Sansom, O. Thomas, P. Brennan, P. Collins, P. Grundy, P. J. Mintz, P. Metherall, P. Singh, P. Singh, P. Szlosarek, P. Tibarewal, P. Welsby, Q. An, R. Beaney, R. Bhangoo, R. Blake, R. Brock, R. G. Tatevossian, R. Grundy, R. Hamilton, R. Hayward, R. Hinz, R. Jackson, R. Jena, R. Lea, R. McConnell, R. Muirhead, R. P. Pangeni, R. Rahman, S. Al-Rashid, S. Ammoun, S. Ammoun, S. Bell, S. Bell, S. Birks, S. Birks, S. Birks, S. Birks, S. Green, S. Hafizi, S. Hafizi, S. Higgins, S. J. Price, S. J. Price, S. J. Price, S. Jefferies, S. Kokkinos, S. Lawler, S. Leow-Dyke, S. Leow-Dyke, S. Leow-Dyke, S. Mashal, S. McQuaid, S. Price, S. Price, S. Price, S. Price, S. Saini, S. Scott, S. Shepherd, S. Smith, S. T. Al Rashid, S. Tavare, S. Wilkins, S. Williams, S. Williams, T. Crook, T. Dawson, T. Dawson, T. Dawson, T. Flannery, T. Flannery, T. Gaissmaier, T. J. Warr, T. Jacques, T. Jaunky, T. Lawson, T. Smith, T. Van Meter, T. Warr, T. Warr, T. Warr, T. Warr, T. Warr, V. Beckett, V. Berry, V. Bosak, V. Brunton, V. Hurwitz, V. Iyer, V. Iyer, V. Lupson, V. Petinou, W. Harkness, W. Stewart, W. Stewart, Y. Majani, Y. Zhang, Z. Hanzely, Z. Hanzely, Z. Maherally, Z. Su +312 morecore +1 more sourceMethods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors
Molecular Therapy: Methods & Clinical Development, 2020 Different approaches are used in the production of recombinant adeno-associated virus (rAAV). The two leading approaches are transiently transfected human HEK293 cells and live baculovirus infection of Spodoptera frugiperda (Sf9) insect cells ...Neil G. Rumachik, Stacy A. Malaker, Nicole Poweleit, Lucy H. Maynard, Christopher M. Adams, Ryan D. Leib, Giana Cirolia, Dennis Thomas, Susan Stamnes, Kathleen Holt, Patrick Sinn, Andrew P. May, Nicole K. Paulk +12 moredoaj +1 more sourceDevelopment and Qualification of an Antigen Integrity Assay for a Plasmodium falciparum Malaria Transmission Blocking Vaccine Candidate, Pfs230
Vaccines, 2022 During development of a subunit vaccine, monitoring integrity of the recombinant protein for process development and quality control is critical. Pfs230 is a leading malaria transmission blocking vaccine candidate and the first to reach a Phase 2 ...Kazutoyo Miura, Thao P. Pham, Shwu-Maan Lee, Jordan Plieskatt, Ababacar Diouf, Issaka Sagara, Camila H. Coelho, Patrick E. Duffy, Yimin Wu, Carole A. Long +9 moredoaj +1 more sourcePotency, Safety, and Pharmacokinetic Profiles of Potential Inhibitors Targeting SARS-CoV-2 Main Protease
Frontiers in Pharmacology, 2021 Effective, safe, and pharmacokinetically suitable drugs are urgently needed to curb the ongoing COVID-19 pandemic. The main protease or 3C-like protease (Mpro or 3CLpro) of SARS-CoV-2 is considered an important target to formulate potent drugs ...Hylemariam Mihiretie Mengist, Hylemariam Mihiretie Mengist, Hylemariam Mihiretie Mengist, Daniel Mekonnen, Daniel Mekonnen, Ahmed Mohammed, Ronghua Shi, Tengchuan Jin, Tengchuan Jin, Tengchuan Jin +9 moredoaj +1 more sourceIchthyofauna of Merbau River, Leuser Ecosystem Area, Indonesia: species composition, diversity, biometric condition, potency, and conservation status
The European Zoological Journal, 2023 The Leuser Ecosystem Area (LEA) is one of the largest conservation areas in Southeast Asia. However, the explorations of ichthyofauna at LEA are still relatively scarce compared to other vertebrates fauna.M. Hidayat, S. Maulizar, A. S. Batubara, N. Kautsari, H. Latuconsina, F. M. Nur, I. Zulfahmi +6 moredoaj +1 more sourcePooled human bone marrow-derived mesenchymal stromal cells with defined trophic factors cargo promote dermal wound healing in diabetic rats by improved vascularization and dynamic recruitment of M2-like macrophages
Frontiers in Immunology, 2022 Human Mesenchymal Stromal Cells (hMSCs) are a promising source for cell-based therapies. Yet, transition to phase III and IV clinical trials is remarkably slow.Hélène Willer, Hélène Willer, Gabriele Spohn, Kimberly Morgenroth, Corinna Thielemann, Susanne Elvers-Hornung, Peter Bugert, Bruno Delorme, Melanie Giesen, Thomas Schmitz-Rixen, Erhard Seifried, Christiane Pfarrer, Richard Schäfer, Richard Schäfer, Richard Schäfer, Karen Bieback, Karen Bieback, Karen Bieback +17 moredoaj +1 more source