Mini review on Potency Evaluation of Rabies Vaccine preparations
Archives of Pharmaceutical Sciences Ain Shams University, 2021 Rabies is considered one of the most harmful viral infections of warm-blooded animals still. Thousands of people are infected with it each year worldwide. It is a fatal disease unless early treatment is received before the appearance of symptoms.
Walaa Rashed +2 more
doaj +1 more source
G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]
, 2015 G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie +4 more
core +3 more sources
A Novel Approach to Assess the Potency of Topical Corticosteroids
Pharmaceutics, 2021 The potencies of topical corticosteroid products have mainly been classified using clinical data but in some instances, the US Food and Drug Administration’s (FDA’s) vasoconstrictor assay (VCA) to assess the skin blanching response has also been used ...
Michael Zvidzayi +4 more
doaj +1 more source
High-potency ligands for DREADD imaging and activation in rodents and monkeys
Nature Communications, 2019 Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well.
J. Bonaventura +24 more
semanticscholar +1 more source
Diet Breadth Mediates the Prey Specificity of Venom Potency in Snakes
Toxins, 2020 Venoms are best known for their ability to incapacitate prey. In predatory groups, venom potency is predicted to reflect ecological and evolutionary drivers relating to diet.
Keith Lyons, Michel M. Dugon, K. Healy
semanticscholar +1 more source
Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels [PDF]
, 2018 Drugs do not act solely by canonical ligand–receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins.
Aldrich, Richard W. +12 more
core +2 more sources
Antibacterial Potency of Honey
International Journal of Microbiology, 2019 Despite the developments in controlling infectious disease around the world, they are still the second biggest cause of morbidity and mortality due in part to the increase in drug resistance among large numbers of the bacterial strains.
N. Albaridi
semanticscholar +1 more source
The Human Penile Fibro-Vascular Assembly Requires the Integrity of Ten Fibro-Ligaments
LifeIntroduction: Penile fibro-ligaments have been extensively studied for many centuries; however, there is, unfortunately, a lack of thorough understanding. We aimed to bridge the research gap between anatomy and surgical reconstruction.
Heng-Shuen Chen +7 more
doaj +1 more source
LifeIntroduction: Herein, we explore whether coil embolization (CE) is effective in treating veno-occlusive dysfunction (VOD). We present five cases with seven CE episodes and a narrative literature review.
Ko-Shih Chang +5 more
doaj +1 more source
Isolation and Characterization of the Novel Botulinum Neurotoxin A Subtype 6
mSphere, 2018 Botulinum neurotoxins (BoNTs), the most potent toxins known to humans and the causative agent of botulism, exert their effect by entering motor neurons and cleaving and inactivating SNARE proteins, which are essential for neurotransmitter release.
Molly S. Moritz +4 more
doaj +1 more source