Results 31 to 40 of about 997,205 (406)

Synthesis and penicillin‐binding protein inhibitory assessment of dipeptidic 4‐phenyl‐β‐lactams from α‐amino acid‐derived imines [PDF]

, 2020
Monocyclic beta-lactams revive the research field on antibiotics, which are threatened by the emergence of resistant bacteria. A six-step synthetic route was developed, providing easy access to new 3-amino-1-carboxymethyl-4-phenyl-beta-lactams, of which ...
Amoroso, Ana Maria, D'hooghe, Matthias, Decuyper, Lena, Gobec, Stanislav, Joris, Bernard, Jukič, Marko, Sosič, Izidor, Verlaine, Olivier   +7 more
core   +2 more sources

Mini review on Potency Evaluation of Rabies Vaccine preparations

Archives of Pharmaceutical Sciences Ain Shams University, 2021
Rabies is considered one of the most harmful viral infections of warm-blooded animals still. Thousands of people are infected with it each year worldwide. It is a fatal disease unless early treatment is received before the appearance of symptoms.
Walaa Rashed, Khaled M. Aboshanab, Mohammad M. Aboulwafa   +2 more
doaj   +1 more source

Mind the gap: Can we explain declining male reproductive health with known antiandrogens? [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Several countries have experienced rises in cryptorchidisms, hypospadias and testicular germ cell cancer. The reasons for these trends are largely unknown, but Skakkebaek
Andreas Kortenkamp, Berkowitz, Birkh  j, Carbone, Carmichael, Chia, Christiansen, Christiansen, Conacher, Covaci, Darbre, Ermler, Ermler, Fromme, Galassi, Hardell, Hardell, Hardell, Janjua, Jensen, Karrman, Karrman, Kjaerstad, Kojima, Kristensen, L  pez-Cervantes, Martin Scholze, Midasch, Neal, Nelson, Orton, Orton, Park, Pierik, Pierik, Rappaport, Schiavone, Schlumpf, Scholze, Sch  nfelder, Sibylle Ermler, Stoker, Suzuki, Swan, Swan, Vandenberg, Vinggaard, Wilson, Wine, You   +49 more
core   +1 more source

Diet Breadth Mediates the Prey Specificity of Venom Potency in Snakes

Toxins, 2020
Venoms are best known for their ability to incapacitate prey. In predatory groups, venom potency is predicted to reflect ecological and evolutionary drivers relating to diet.
Keith Lyons, Michel M. Dugon, K. Healy
semanticscholar   +1 more source

A Novel Approach to Assess the Potency of Topical Corticosteroids

Pharmaceutics, 2021
The potencies of topical corticosteroid products have mainly been classified using clinical data but in some instances, the US Food and Drug Administration’s (FDA’s) vasoconstrictor assay (VCA) to assess the skin blanching response has also been used ...
Michael Zvidzayi, Seeprarani Rath, Charles Bon, Sagaran Abboo, Isadore Kanfer   +4 more
doaj   +1 more source

Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis [PDF]

, 2013
Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity ...
Bailey H. H., Ballestrero A., Bellamy W. T., Betanzos-Lara S., Bozic I., Bushra Qamar, Carew J. S., Castonguay A., Chan J., Constantini P., Dai Y., Degterev A., Dindo D., Doroshow J. H., Dyke M. W. Van, Fagan V., Finnilä S., Frank J. E., Fu Y., Fu Y., Gaiddon C., Garbutcheon-Singh K. B., Hannon M. J., Hartinger C. G., Hileman E. A., Holbeck S., Huo H., Ian Hands-Portman, Isolda Romero-Canelón, Jessica M. Hearn, Jordan M. A., Jungwirth U., Kelland L., Kerr J. F., Kroemer G., Lazebnik Y. A., Liu Z., Liu Z., Liu Z., Lu J.-J., McKeage M. J., Millar A. W., Monneret C., Nagata S., Park G. Y., Paull K., Perchellet E. M., Peter J. Sadler, Petrelli A., Pittella F., Porteous C. M., Pracharova J., Purewal M., Rai S. S., Rixe O., Saraste A., Shoemaker R. H., Shoemaker R. H., Siddik Z., Sidler D., Tsutsui T., Türk D., Van den Bogert C., Zalacaín M., Zhang Y.-W., Zhe Liu, Zhou D.-F., Zhu Z.   +67 more
core   +1 more source

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators [PDF]

, 2016
This Letter was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Scottish Universities Life Sciences Alliance (SULSA) in 2011Peer ...
Abdelrahman, Mostafa Hamed, Baillie, Gemma L., Greig, Iain R., Ross, Ruth A., Trembleau, Laurent   +4 more
core   +1 more source

High-potency ligands for DREADD imaging and activation in rodents and monkeys

Nature Communications, 2019
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well.
J. Bonaventura, M. Eldridge, Feng Hu, Juan L. Gomez, Marta Sánchez-Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, C. Ruiz, M. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, R. Moaddel, Patrick J. Morris, Lei Shi, D. Sibley, S. Mahler, S. Nabavi, M. Pomper, A. Bonci, A. Horti, B. Richmond, M. Michaelides   +24 more
semanticscholar   +1 more source

The Human Penile Fibro-Vascular Assembly Requires the Integrity of Ten Fibro-Ligaments

Life
Introduction: Penile fibro-ligaments have been extensively studied for many centuries; however, there is, unfortunately, a lack of thorough understanding. We aimed to bridge the research gap between anatomy and surgical reconstruction.
Heng-Shuen Chen, Chu-Wen Fang, Raymond W. M. Tsai, Chih-Yuan Hsu, Geng-Long Hsu, Hsiu-Chen Lu, Mang-Hung Tsai, Jeff S. C. Chueh   +7 more
doaj   +1 more source

Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture [PDF]

, 2009
Pyrrole−imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture.
Dervan, Peter B., Jacobs, Claire S.
core   +2 more sources