Results 91 to 100 of about 468,048 (310)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Evaluation and comparison of Hela, Hep2C and Vero cell lines sensitivity to polio vaccinal virus using micro and macro vaccine potency tests

Archives of Razi Institute, 2012
Poliomyelitis, an acute viral infectious disease caused by poliovirus, still remains a public health problem in developing countries. Despite the global effort to eradicate polio, continuing the polio immunization with a potent and safe vaccine is ...
Soleimani, S.,, Abedi Kiasari, B.
doaj  

Mechanism of action, potency and efficacy: considerations for cell therapies

Journal of Translational Medicine
One of the most challenging aspects of developing advanced cell therapy products (CTPs) is defining the mechanism of action (MOA), potency and efficacy of the product. This perspective examines these concepts and presents helpful ways to think about them
Carl G. Simon, Erich H. Bozenhardt, Christina M. Celluzzi, David Dobnik, Melanie L. Grant, Uma Lakshmipathy, Thiana Nebel, Linda Peltier, Anthony Ratcliffe, James L. Sherley, Glyn N. Stacey, Rouzbeh R. Taghizadeh, Eddie H. P. Tan, Sandrine Vessillier   +13 more
doaj   +1 more source

In vitro potency test for evaluation of Clostridium perfringens type D epsilon toxoid

Arquivos do Instituto Biológico
The control of enterotoxemia caused by the epsilon toxin, produced by Clostridium perfringenstype D, is based on vaccination with epsilon toxoid. The potency test for this immunogen is conducted using seroneutralization in mice.
Felipe Masiero Salvarini, Zélia Ines Portela Lobato, Prhiscylla Sadanã Pires, Rodrigo Otávio Silveira Silva, Guilherme Guerra Alves, Pedro Lúcio Lithg Pereira, Francisco Carlos Faria Lobato   +6 more
doaj   +1 more source

Development of a fast and precise potency test for BCG vaccine viability using flow cytometry compared to MTT and colony-forming unit assays. [PDF]

Sci Rep, 2023
Moghawry HM, Rashed ME, Gomaa K, AbdelGhani S, Dishisha T.   +4 more
europepmc   +1 more source

Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function [PDF]

, 2006
Following inducible expression in HEK293 cells, the human orexin-1 receptor was targeted to the cell surface but became internalized following exposure to the peptide agonist orexin A.
Canals Buj, M., Ellis, J., Milasta, S., Milligan, G., Pediani, J.D.   +4 more
core   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Mathematical modeling for determining the potency of bovine tuberculin purified protein derivative (P.P.D.) [PDF]

Medicamentul Veterinar, 2015
Bovine tuberculin purified protein derivative (bovine tuberculin PPD) is a preparation obtained from the heat-treated products of growth and lysis of Mycobacterium bovis, strain AN5, purified and solubilized into a liquid preservative, buffered ...
Viviana Ciuca, Victorita Burghelea, Mihai Danes, Viorel V. Safta , Olga Casu, Ramona Niculicioiu   +5 more
doaj  

Short communication: Feasibility of dengue vaccine to infect different human cell lines: An alternative potency test using HEK293T cells. [PDF]

PLoS One, 2022
Faria de Carvalho R, de Siqueira Penna Quintaes L, de Cássia de Souza Su T, Mitiko Kobayashi L, Martins de Almeida Nogueira AC.   +4 more
europepmc   +1 more source

Antibacterial Activity of Culture Extracts of Penicillium chrysogenum PCL501: Effects of Carbon Sources [PDF]

, 2009
Penicillium chrysogenum PCL501 produced β-lactam antibiotics when fermented with different agro-wastes: cassava shavings, corncob, sawdust and sugarcane pulp.
Chinedu, SN, Okafor, UA, Okochi, VI, Onyegeme-Okerenta, BM   +3 more
core   +1 more source