Results 261 to 270 of about 469,402 (307)

Improved potency test for live avian encephalomyelitis vaccines

Research in Veterinary Science, 1986
Potency tests were carried out on live avian encephalomyelitis virus (AEV) vaccines. Vaccines were titrated in chick embryo brain cell cultures using an indirect fluorescent antibody test just before vaccination. Groups of chickens were inoculated orally with graded doses of each vaccine. After three weeks serum was taken from the chickens and examined
R A, Nicholas, R D, Goddard, A J, Ream, I G, Hopkins, D H, Thornton   +4 more
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A potency test for live Newcastle disease vaccines

Journal of Biological Standardization, 1980
The potency of live Newcastle disease vaccines was assessed by means of a multi-point challenge assay in vaccinated chicks. The assay was shown to give reproducible results and to be capable of detecting significant differences between the protective capacities of various vaccines.
D H, Thornton, C N, Hebert
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Relative mutagenic potencies determined in the micronucleus test

Journal of Theoretical Biology, 1978
Abstract Data from two publications which include dose-response data were subject to model fitting using a Poisson distribution and a linear dose-response function. In Swiss mice, acetylaminofluorene was the weakest mutagen tested. Aflatoxin B 1 , 3-methylcholanthrene and dimethylnitrosamine were 66, 14, and 140 times as potent, respectively.
M A, Friedman, W H, Carter, J, Staub, A, Segreti   +3 more
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A Guinea Pig Potency Test for Adenovirus Vaccine

The Journal of Immunology, 1960
Summary An assay for potency of adenovirus vaccine in guinea pigs based on the antigen extinction principle is described. The potency test values in repeat titrations were reproducible within a maximal 7-fold range. Further need for control with a standard reference vaccine is indicated. Potency values for a number of vaccines of diverse
L N, BINN, M R, HILLEMAN
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A One-Dose Potency Test for Poliomyelitis Vaccine

The Journal of Immunology, 1965
Summary Studies leading to the development and use of a one-dose potency test for poliomyelitis vaccine are described. The test is based on the measurement of neutralizing antibody in the serum of 6-week-old chickens that received one dose of a single dilution of vaccine.
R M, VANFRANK, M L, HAVENS, J O, MACFARLANE, A V, BOAND, B E, KIRK, R J, HOSLEY   +5 more
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Rabies Vaccine Potency and Stability Testing

1988
It is 100 years since Louis Pasteur carried out the first immunization of humans against rabies virus infection. Although great advances have been made in the development of more effective and purified vaccines, vaccines produced in adult or suckling animal nervous tissue are still in use in many countries.
Morag Ferguson, Valerie Seagroatt, G. C. Schild   +2 more
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Potency testing of killed polio vaccine in rats.

Developments in biological standardization, 1980
Various laboratory animal species were considered for testing the potency of killed poliovaccine. The rat appeared most suitable for obtaining quantitative information by measuring the titre of the antibody response. There was, in general, a good correlation between antibody response in rats and D-antigen titre.
van Steenis, G, van Wezel, AL, Sekhuis, VM   +2 more
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Potency testing of bovine tuberculins.

Developments in biological standardization, 1987
The diagnosis of bovine tuberculosis is based on the intradermal tuberculin test. Therefore in eradication campaigns HCSM or PPD tuberculins with high potency and maximal specificity per cattle dose are needed. In quality control and standardization assays the PPD tuberculins have the advantage that the protein content can serve as a basis for ...
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Release potency tests of hepatitis vaccines.

Developments in biological standardization, 1999
SmithKline Beecham Biologicals produces two vaccines against hepatitis: hepatitis B (Engerix-B) introduced in 1986 and hepatitis A (Havrix) introduced in 1991. Using these two examples, we demonstrate the long and gradual transition process towards an in vitro release test for potency and a significant decrease in the number of animals needed for ...
J, Descamps, A, Mary, E, Rommel, M L, Anhoury, R, De Neys, M, Duchêne   +5 more
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Potency testing of bacterial vaccines for human use

Veterinary Microbiology, 1993
The potency tests for bacterial vaccines are quite diverse. For some products (pertussis, cholera, anthrax, typhoid and BCG vaccines) these are specified as Additional Standards in the Code of Federal Regulations. For other products (tetanus and diphtheria toxoids, plague vaccine) the testing is done according to so-called Minimum Requirements, which ...
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