Results 61 to 70 of about 241,473 (261)

A MODEL TO TEST THE POTENCY OF INHALATION ANAESTHETICS

British Journal of Anaesthesia, 1989
The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415 ...
J D, McKenzie, P, Calow, W S, Nimmo
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mathematical modeling for determining the potency of bovine tuberculin purified protein derivative (P.P.D.) [PDF]

Medicamentul Veterinar, 2015
Bovine tuberculin purified protein derivative (bovine tuberculin PPD) is a preparation obtained from the heat-treated products of growth and lysis of Mycobacterium bovis, strain AN5, purified and solubilized into a liquid preservative, buffered ...
Viviana Ciuca, Victorita Burghelea, Mihai Danes, Viorel V. Safta , Olga Casu, Ramona Niculicioiu   +5 more
doaj  

Short communication: Feasibility of dengue vaccine to infect different human cell lines: An alternative potency test using HEK293T cells. [PDF]

PLoS One, 2022
Faria de Carvalho R, de Siqueira Penna Quintaes L, de Cássia de Souza Su T, Mitiko Kobayashi L, Martins de Almeida Nogueira AC.   +4 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Stability Study of Razi Trivalent and Monovalent Oral Poliomyelitis Vaccine

Archives of Razi Institute, 2012
Stability studies play a critical role in assuring product quality at all points in the vaccine life cycle. These studies used to determine vaccine expiry date and vaccine efficacy.
Soleimani, S., Bordbar, N.
doaj  

Purslane Herb (Portulaca grandiflora) Ointment Antibacterial Potency against Staphylococcus aureus

Florea: Jurnal Biologi dan Pembelajarannya
Recent research showed that the rose-like purslane (Portulaca grandiflora) magenta flower variety herbs ethanolic extract has antimicrobial potency. This research aims to determine the purslane herbs (Portulaca grandiflora) extract ointment antimicrobial
Agus Purwanto, Antonius Budiawan, Christianto Adhy Nugroho, Christina Indriasari   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Humane endpoints in vaccine potency testing

Procedia in Vaccinology, 2011
AbstractVaccine potency and safety testing is characterized by extensive use of laboratory animals and a relatively high percentage of test methods that involve severe pain and distress. This is particularly true for tests that are based on infection or challenge with a virulent microorganism.
openaire   +1 more source