Results 41 to 50 of about 247,875 (263)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Refinement of Vaccine Potency Testing with the Use of Humane Endpoints [PDF]
ILAR Journal, 2000 Published results of a poll taken in the United Kingdom about public views on animal experimentation (Aldhous et al. 1999) reveal that people provided with impartial informa- tion appear to weigh the pros and cons of each experiment carefully before deciding whether they are willing to support the use of animals in research.
Hendriksen, CFM, Steen, B
openaire +4 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Designing highly potent compounds using a chemical language model
Scientific Reports, 2023 Compound potency prediction is a major task in medicinal chemistry and drug design. Inspired by the concept of activity cliffs (which encode large differences in potency between similar active compounds), we have devised a new methodology for predicting ...
Hengwei Chen, Jürgen Bajorath
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Archives of Razi Institute, 2016 Stability studies play a critical role in assuring product quality at all points in the vaccine life cycle and have a major impact on the success of immunization programs worldwide.
Soleimani, S.
doaj
POTENSI JUS BUAH PARE (Momordica charantia L.) SEBAGAI PENGHAMBAT HEMOGLOBIN TERGLIKASI IN VITRO
Berkala Kedokteran, 2015 Bitter gourd (Momordica charantia) is a fruit that is potentially has the ability to inhibit glycated hemoglobin thus can reduce blood sugar level. The aim of this study is to test the potency of bitter gourd juice as a glycated hemoglobin inhibitor ...
Muhammad Topan Widyanto +2 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source