Results 61 to 70 of about 247,875 (263)

Mechanism of action, potency and efficacy: considerations for cell therapies

Journal of Translational Medicine
One of the most challenging aspects of developing advanced cell therapy products (CTPs) is defining the mechanism of action (MOA), potency and efficacy of the product. This perspective examines these concepts and presents helpful ways to think about them
Carl G. Simon, Erich H. Bozenhardt, Christina M. Celluzzi, David Dobnik, Melanie L. Grant, Uma Lakshmipathy, Thiana Nebel, Linda Peltier, Anthony Ratcliffe, James L. Sherley, Glyn N. Stacey, Rouzbeh R. Taghizadeh, Eddie H. P. Tan, Sandrine Vessillier   +13 more
doaj   +1 more source

Development of a fast and precise potency test for BCG vaccine viability using flow cytometry compared to MTT and colony-forming unit assays. [PDF]

Sci Rep, 2023
Moghawry HM, Rashed ME, Gomaa K, AbdelGhani S, Dishisha T.   +4 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evaluation and comparison of Hela, Hep2C and Vero cell lines sensitivity to polio vaccinal virus using micro and macro vaccine potency tests

Archives of Razi Institute, 2012
Poliomyelitis, an acute viral infectious disease caused by poliovirus, still remains a public health problem in developing countries. Despite the global effort to eradicate polio, continuing the polio immunization with a potent and safe vaccine is ...
Soleimani, S.,, Abedi Kiasari, B.
doaj  

In vitro potency test for evaluation of Clostridium perfringens type D epsilon toxoid

Arquivos do Instituto Biológico
The control of enterotoxemia caused by the epsilon toxin, produced by Clostridium perfringenstype D, is based on vaccination with epsilon toxoid. The potency test for this immunogen is conducted using seroneutralization in mice.
Felipe Masiero Salvarini, Zélia Ines Portela Lobato, Prhiscylla Sadanã Pires, Rodrigo Otávio Silveira Silva, Guilherme Guerra Alves, Pedro Lúcio Lithg Pereira, Francisco Carlos Faria Lobato   +6 more
doaj   +1 more source

Short communication: Feasibility of dengue vaccine to infect different human cell lines: An alternative potency test using HEK293T cells. [PDF]

PLoS One, 2022
Faria de Carvalho R, de Siqueira Penna Quintaes L, de Cássia de Souza Su T, Mitiko Kobayashi L, Martins de Almeida Nogueira AC.   +4 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Stability Study of Razi Trivalent and Monovalent Oral Poliomyelitis Vaccine

Archives of Razi Institute, 2012
Stability studies play a critical role in assuring product quality at all points in the vaccine life cycle. These studies used to determine vaccine expiry date and vaccine efficacy.
Soleimani, S., Bordbar, N.
doaj  

Mathematical modeling for determining the potency of bovine tuberculin purified protein derivative (P.P.D.) [PDF]

Medicamentul Veterinar, 2015
Bovine tuberculin purified protein derivative (bovine tuberculin PPD) is a preparation obtained from the heat-treated products of growth and lysis of Mycobacterium bovis, strain AN5, purified and solubilized into a liquid preservative, buffered ...
Viviana Ciuca, Victorita Burghelea, Mihai Danes, Viorel V. Safta , Olga Casu, Ramona Niculicioiu   +5 more
doaj  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source