Results 141 to 150 of about 542,663 (313)
High-speed rail’s impact on the location of office employment within the Dutch Randstad area [PDF]
With the upcoming implementation of high-speed railway infrastructure in the Netherlands, interest has arisen in the spatial-economic effects this might have.
Bert Van Wee +2 more
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Advances in Climate Change ResearchWinter roads, which are seasonal roads built on frozen surfaces, serve as a socio-economic lifeline in the pan-Arctic region but are sensitive to amplified Arctic warming.
Li-Yuan Chen +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Centre-Periphery Analysis About the Hungarian Public Road System [PDF]
Although the European Union prefers and supports mostly railways in terms of transport investments, the public road network – with a special regard to motorways – is rather underdeveloped in Hungary.
Geza Toth
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
SPATIAL ACCESSIBILITY OF HEALTH CARE IN INDIANA [PDF]
Healthy populations and access to health care services are significant factors influencing economic development and prosperity. Since geographic access is an essential feature of an overall health system, it is important for health service researchers to
Brigitte S. WALDORF +2 more
core
Potential accessibility distance to primary equipment (example for GPs).
, 2019 Potential accessibility distance to primary equipment (example for GPs).
Mohand Medjkane (7299995) +6 more
core +1 more source