Results 121 to 130 of about 542,663 (313)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The relation between modeled and perceived accessibility [PDF]
This thesis investigates the relationship between modeled and perceived accessibility across different activities and transport modes. Accessibility is important for people’s daily lives as it enables them to reach and carry out various activities.
Vafeiadis, Evangelos
core +1 more source
Romania’s Accession to Second Modernity. Potential of Convergence
Theoretical and Applied Economics, 2006 This paper analyses Romanian economy facing with European integration process at 2007. The Romanian economy advanced the development prudent macroeconomics policies and implement structural reforms in the market for goods, labor and financial products. We identify in this study the principal conditionalities for the admittance in European Union.
Marin Dinu, Cristian Socol
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Place Rank: Valuing Spatial Interactions [PDF]
Accessibility measures the potential of opportunities for interaction. This paper proposes and explores a new flow-based measure, 'place rank' using origin-destination information.
Ahmed El-Geneidy, David Levinson
core
Quaestiones GeographicaeThe Sub-Tatra region, which includes Orava, Liptov, and Spiš regions, is an area with high geodiversity and biodiversity. This diversity is manifested, among others, by the occurrence of geosites of special cognitive, educational, and tourist value. This
Chrobak-Žuffová Anna +2 more
doaj +1 more source
An International Comparison of Equity in Accessibility to Jobs: London, São Paulo and the Randstad
Findings, 2019 We analyze the impact of different accessibility measures on the interpretation of associated equity analysis using the Gini Coefficient and the (pseudo) Palma Ratio, and the impact of the method of assigning zonal accessibility on Gini estimation ...
John P. Pritchard +3 more
doaj +1 more source
Differences in the Potential Accessibility of Home-Based Healthcare Services among Different Groups of Older Adults: A Case from Shaanxi Province, China. [PDF]
Healthcare (Basel), 2020 Wang L, Di X, Yang L, Dai X.
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source