Results 111 to 120 of about 15,304,650 (294)

Abuse potential assessment of the dual orexin receptor antagonist daridorexant in rats. [PDF]

J Psychopharmacol, 2023
Steiner MA, Toeroek-Schafroth M, Giusepponi ME, Dacome L, Tessari M.   +4 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Status Report on the Gas Potential From Devonian Shales of the Appalachian Basin [PDF]

, 1977
A report by the Office of Technology Assessment (OTA) of "the potential for producing gas from the Devonian shales of the Appalachian Basin" based on "plausible economic, geologic, and technological assumptions" (Foreward)
United States. Congress. Office of Technology Assessment.
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Environmental Assessment of the Expansion of the Mountain View Sewerage Treatment Facilities, Wayne Township, New Jersey

, 1973
This report covers in detail all of the various and varying areas and concepts contained in the "Environmental Assessment Outline: Wayne Township". It includes: a description of the proposed project; background information on the geography, natural ...

core   +1 more source

Evaluating Scientific Potential in Kazakhstan: A Regional Index Assessment Approach

Экономика: стратегия и практика
The role of human resources in increasing competitiveness is enormous, including people with higher education, a certain status or academic degree, as well as knowledgeable human resources.
O. S. Adilkhanov, O. S. Sabden, Sh. K. Turdalina, Sh. Zh. Tuebekova   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

What can e-assessment do for learning and teaching? Part 1 of a draft of current and emerging practice review by the e-Assessment Association expert panel

, 2012
This paper serves as part of a review by the e-Assessment Association (eAA) in its desire to make a positive contribution to the assessment arena.
Beevers, Cliff, al., et
core  

Artificial intelligence applied to potential assessment and talent identification in an organisational context. [PDF]

Heliyon, 2023
Jacob Fernandes França T, São Mamede H, Pereira Barroso JM, Pereira Duarte Dos Santos VM.   +3 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source