Results 111 to 120 of about 2,450,637 (403)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Use of a mobile application for Ebola contact tracing and monitoring in northern Sierra Leone: a proof-of-concept study

BMC Infectious Diseases, 2019
Background The 2014–2016 Ebola epidemic in West Africa was the largest Ebola epidemic to date. Contact tracing was a core surveillance activity. Challenges with paper-based contact tracing systems include incomplete identification of contacts, delays in ...
Lisa O. Danquah, Nadia Hasham, Matthew MacFarlane, Fatu E. Conteh, Fatoma Momoh, Andrew A. Tedesco, Amara Jambai, David A. Ross, Helen A. Weiss   +8 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Socioeconomic inequalities in mortality among Italian and immigrant residents: A longitudinal population-based study

Journal of Migration and Health
Background: A socioeconomic mortality gradient, favourable to the most advantaged social groups, has been documented in high migratory pressure (HMPCs) and highly developed countries, including Italy.
Martina Ventura, Alessio Petrelli, Anteo Di Napoli, Sara Leone, Enrico Grande, Marilena Pappagallo, Luisa Frova   +6 more
doaj   +1 more source

Doing More for Our Children: Modeling a Universal Child Allowance or More Generous Child Tax Credit [PDF]

, 2016
Child poverty in the United States remains stubbornly high, with 12.2 million children living in poverty in 2013. Nearly 17 percent of children in the United States lived in poverty in 2013 -- a higher rate than for other age groups, and considerably ...
Christopher Wimer, David Harris, Irwin Garfinkel, Jane Waldfogel   +3 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Role of the Skin Immune System in Wound Healing

Cells
Wound healing is a dynamic and complex process, characterized by the coordinated activities of multiple cell types, each with distinct roles in the stages of hemostasis, inflammation, proliferation, and remodeling. The cells of the immune system not only
Angela Cioce, Andrea Cavani, Caterina Cattani, Fernanda Scopelliti   +3 more
doaj   +1 more source

Shedding light on quality of care: a study protocol for a randomized trial evaluating the impact of the Solar Suitcase in rural health facilities on maternal and newborn care quality in Uganda

BMC Pregnancy and Childbirth, 2019
Background Continued progress in reducing maternal and newborn morbidity and mortality in low-income countries requires a renewed focus on quality of delivery care.
Slawa Rokicki, Brian Mwesigwa, Laura Schmucker, Jessica L. Cohen   +3 more
doaj   +1 more source

The government's child poverty target: how much progress has been made? [PDF]

, 2002
Before the 2001 election the Treasury said that `tax and benefit reforms announced in this Parliament will lift over 1.2 million children out of relative poverty'.
Brewer, M., Clark, T., Goodman, A.
core  

Poverty and health [PDF]

Canadian Medical Association Journal, 2006
Health and poverty are inextricably intertwined. Being able to breast-feed, attend school, work to grow food, earn a living or feed a family all depend on a baseline level of good health. Yet, when more than a billion people live on less than $1 per day and 2 billion on less than $2 a day, many ...
openaire   +2 more sources