Results 111 to 120 of about 2,092,140 (361)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Reply to: Intergenerational nutrition benefits of India’s national school feeding program: Reality or a bridge too far?

open access: yesNature Communications, 2022
Suman Chakrabarti   +4 more
doaj   +1 more source

Poverty, Deprivation and Consistent Poverty*

open access: yesEconomic Record, 2009
Controversy over the setting of poverty lines and its narrow focus on income has undermined the influence of poverty research on policy. The deprivation approach overcomes these limitations by identifying deprivation as an inability to afford items that receive majority support for being essential.
Saunders, Peter, Naidoo, Yuvisthi
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Child Poverty [PDF]

open access: yes, 2011
This is a collection of papers written by members of the Social Policy Association about the impact of the Coalition Government's Comprehensive Spending Review of October 2010 on areas of the welfare state.
openaire   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Doing More for Our Children: Modeling a Universal Child Allowance or More Generous Child Tax Credit [PDF]

open access: yes, 2016
Child poverty in the United States remains stubbornly high, with 12.2 million children living in poverty in 2013. Nearly 17 percent of children in the United States lived in poverty in 2013 -- a higher rate than for other age groups, and considerably ...
Christopher Wimer   +3 more
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

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