Results 81 to 90 of about 1,962,520 (360)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Building new social contracts: a critical review of ideas and actions to fulfill African aspirations through education

National Accounting Review
This article proposes a theoretical framework for constructing a new social contract through education based on three levers—affordability, accessibility, and applicability—focusing on Africa.
Sweta C. Saxena, Giuseppe Tesoriere, Syed T. Ahmed, Wafa Aidi   +3 more
doaj   +1 more source

Poverty and Disability: The Endless Loop [PDF]

, 2006
[Excerpt] Disability is a critical dimension of poverty in developing countries because poverty contributes to disability and disability leads to poverty.
Hutchinson, Kim
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Working to Reduce Poverty: A National Subsidized Employment Proposal

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2018
Subsidized employment programs that increase labor supply and demand are a proven, underutilized strategy for reducing poverty in the short and long term.
Indivar Dutta-Gupta, Kali Grant, Julie Kerksick, Dan Bloom, Ajay Chaudry   +4 more
doaj   +1 more source

2007 Report on Illinois Poverty [PDF]

, 2007
This seventh annual Report on Illinois Poverty illustrates that there are many indications Illinois families are experiencing significant hardship. Over one third of Illinoisans in poverty are children, disparities in income and wealth are widening ...

core  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

A local government authority leading action research: Impacts and replicability

Commonwealth Journal of Local Governance, 2010
The paper explores whether the institutional model of the IDRC Colombo Focus City Project has had an impact on overcoming challenges associated with research based learning designed to influence policy and implementation processes of local government ...
Neranjana Gunetilleke
doaj   +1 more source

Poverty Matters: It's Now 50/50, Chicago Region Poverty Growth is a Suburban Story [PDF]

, 2013
Nationwide, the number of people in poverty in the suburbs has now surpassed the number of people in poverty in central cities. Cities have long been thought to be home to the most and worst poverty. However, in the past several decades, the suburbs have
Amy Terpstra, Jennifer Clary, Nicole Kreisberg   +2 more
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