Results 61 to 70 of about 955,310 (294)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Preface: The 4th Annual Conference Solar and Wind Power

Engineering Proceedings
The 4th Annual Conference on Solar and Wind Power, organised by the School of Computing, Engineering, and the Built Environment at Edinburgh Napier University, took place on the 5th of June, 2024 [...]
Nazmi Sellami, Firdaus Muhammad-Sukki, Pablo Sola   +2 more
doaj   +1 more source

Two‐stage ANN‐based bidding strategy for a load aggregator using decentralized equivalent rival concept

IET Generation, Transmission & Distribution, 2021
As an intermediator between the wholesale electricity market and retail market, a typical load aggregator submits an optimal bid to the system operator to meet the expected demands of its customers.
Mohammad Kiannejad, Mohammad Reza Salehizadeh, Majid Oloomi‐Buygi   +2 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Performance Evaluation of Distributed Computing Environments with Hadoop and Spark Frameworks

, 2017
Recently, due to rapid development of information and communication technologies, the data are created and consumed in the avalanche way. Distributed computing create preconditions for analyzing and processing such Big Data by distributing the ...
Alienin, Oleg, Gordienko, Yuri, Rojbi, A., Stirenko, Sergii, Taran, Vladyslav   +4 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Techno-Economic Analysis of Common Work of Wind and Combined Cycle Gas Turbine Power Plant by Offering Continuous Level of Power to Electricity Market

Journal of Sustainable Development of Energy, Water and Environment Systems, 2018
Wind power varies over time and variations occur on all time scales, mainly under the influence of meteorological fluctuations. Understanding these variations and their predictability is of key importance for integration and optimal utilisation of wind ...
Željko Tomšić, Ivan Rajšl, Matea Filipović   +2 more
doaj   +1 more source

High‐performance computing of 3D blasting wave propagation in underground rock cavern by using 4D‐LSM on TianHe‐3 prototype E class supercomputer

Deep Underground Science and Engineering, 2022
Parallel computing assigns the computing model to different processors on different devices and implements it simultaneously. Accordingly, it has broad applications in the numerical simulation of geotechnical engineering and underground engineering, of ...
Meng Fu, Gaofeng Zhao
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Solving differential‐algebraic equations in power system dynamic analysis with quantum computing

Energy Conversion and Economics
Power system dynamics are generally modeled by high dimensional non‐linear differential‐algebraic equations (DAEs) given a large number of components forming the network.
Huynh T. T. Tran, Hieu T. Nguyen, Long T. Vu, Samuel T. Ojetola   +3 more
doaj   +1 more source