Results 61 to 70 of about 957,228 (296)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
IET Generation, Transmission & Distribution, 2021 As an intermediator between the wholesale electricity market and retail market, a typical load aggregator submits an optimal bid to the system operator to meet the expected demands of its customers.
Mohammad Kiannejad +2 more
doaj +1 more source
A local lattice Boltzmann method for multiple immiscible fluids and dense suspensions of drops [PDF]
, 2011 The lattice Boltzmann method (LBM) for computational fluid dynamics benefits from a simple, explicit, completely local computational algorithm making it highly efficient. We extend LBM to recover hydrodynamics of multi-component immiscible fluids, whilst
Care, Chris +2 more
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Preface: The 4th Annual Conference Solar and Wind Power
Engineering ProceedingsThe 4th Annual Conference on Solar and Wind Power, organised by the School of Computing, Engineering, and the Built Environment at Edinburgh Napier University, took place on the 5th of June, 2024 [...]
Nazmi Sellami +2 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Performance Evaluation of Distributed Computing Environments with Hadoop and Spark Frameworks
, 2017 Recently, due to rapid development of information and communication technologies, the data are created and consumed in the avalanche way. Distributed computing create preconditions for analyzing and processing such Big Data by distributing the ...
Alienin, Oleg +4 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Journal of Sustainable Development of Energy, Water and Environment Systems, 2018 Wind power varies over time and variations occur on all time scales, mainly under the influence of meteorological fluctuations. Understanding these variations and their predictability is of key importance for integration and optimal utilisation of wind ...
Željko Tomšić +2 more
doaj +1 more source