Results 61 to 70 of about 133,467 (304)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Yuanzineng kexue jishu, 2023 Transient statistics is a significant process in nuclear power plant, and is closely related to the operation monitoring and life extension of nuclear power plant.
BAI Xiaoming1;YU Xinyang1;CAO Guochang2;LI Zheng1;CAO Hongsheng2;CUI Huaiming1;AI Honglei1;XIONG Furui1;JIANG He2
doaj +1 more source
Characterisation of the cold metal transfer (CMT) process and its application for low dilution cladding [PDF]
, 2011 The process characteristics of the synergic cold metal transfer (CMT) process have been examined for welding aluminium alloy. Utilising a simple backlighting system and through the arc monitoring the droplet transfer modes were identified.
Lunt, M. +2 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Investigation of gas circulator response to load transients in nuclear power plant operation [PDF]
, 2012 Gas circulator units are a critical component of the Advanced Gas-cooled Reactor (AGR), one of the nuclear power plant (NPP) designs in current use within the UK.
Campbell, Graeme +3 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Defining the nodal equivalent parameters using synchrophasor measurements
MATEC Web of Conferences, 2018 The method for defining the nodal equivalent parameters of grid elements based on synchrophasor measure-ments during transients in a power system is proposed.
Berdin Alexander +2 more
doaj +1 more source
Efficient modelling of natural gas pipeline on electromagnetic transient simulation programs
IET Renewable Power Generation, 2023 Electromagnetic transient programs (EMTPs) are widely used for simulating electromagnetic transient in power systems. With the increasing interest in integrated energy system (IES), it would be beneficial to extend the scope of EMTP‐type application to ...
Ruikai Song +6 more
doaj +1 more source
Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots [PDF]
, 1993 Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate.
Aronson +45 more
core +1 more source