Results 121 to 130 of about 31,022 (291)

Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors. [PDF]

, 2011
Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans.
A Alcami, A Alcami, A Harari, A Harari, A Subramanian, Abdelali Filali-Mouhim, AD Bins, AJ McNeil, Alexandre Harari, Anke Redeker, Antonio Lanzavecchia, B Perdiguero, Beatriz Perdiguero, Bertram L. Jacobs, Carmen E. Gomez, CE Gomez, CE Gomez, CE Gomez, CF Ockenhouse, CJM Melief, Clive Gray, Cornelis J. M. Melief, D Chaussabel, D Gaucher, David M. Koelle, DD Richman, DH O'Connor, DR Burton, E Paoletti, E Tryniszewska, Elias K. Haddad, Esther D. Quakkelaar, Federica Sallusto, Ferry Ossendorp, G Sutter, Giuseppe Pantaleo, GK Smith, J Tartaglia, J Tartaglia, JA Espmark, JA Symons, Jean-Philippe Goulet, Jim Tartaglia, JL Najera, JL Najera, Karen V. Kibler, L Jing, L Jing, LJ Sigal, M Carrington, M Esteban, M Terajima, Mariano Esteban, ME Perkus, ME Perkus, MJ Kuroda, MP Longhi, N Frahm, N Frahm, N Oguiura, N Romani, N van Montfoort, NA Wilson, Nikki M. Loof, OR Colamonici, P Mooij, P Mooij, PA Bart, Paul Heinen, RA Koup, Rafick P. Sékaly, RN Van Gelder, RP Sekaly, S Guerra, S McCormack, S Rerks-Ngarm, SA Migueles, SS Jackson, Stella Mayo McCaughey, Thomas Duhen, X Shen, X Wei, Y Benjamini, Z Hel, Z Hel   +84 more
core   +4 more sources

Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis

Acta Biochimica et Biophysica Sinica, 2018
Lung cancer has a high morbidity rate worldwide and is often resistant to therapy. Oncolytic virus therapy is a developing trend for cancer treatment. Thus, we constructed an oncolytic poxvirus carrying human trail gene that expresses a membrane-binding ...
Jinqing Hu, Huaiyuan Wang, Jin-fa Gu, Xinyuan Liu, Xiu-mei Zhou   +4 more
semanticscholar   +1 more source

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, Volume 8, Issue 9, September 2025.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Comparative biochemical and functional analysis of viral and human secreted tumor necrosis factor (TNF) decoy receptors [PDF]

, 2015
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. The blockade of tumor necrosis factor (TNF) by etanercept, a soluble version of the human TNF receptor 2 (hTNFR2), is a well established strategy to inhibit adverse TNF-mediated ...
Alcamí, Antonio, Alejo, Alí, Pontejo, Sergio M.   +2 more
core   +1 more source

The 2.1 Å structure of protein F9 and its comparison to L1, two components of the conserved poxvirus entry-fusion complex

Scientific Reports, 2018
The poxvirus F9 protein is a component of the vaccinia virus entry fusion complex (EFC) which consists of 11 proteins. The EFC forms a unique apparatus among viral fusion proteins and complexes. We solved the atomic structure of the F9 ectodomain at 2.10 
U. Diesterbeck, A. Gittis, D. Garboczi, B. Moss   +3 more
semanticscholar   +1 more source

Genome Variability and Gene Content in Chordopoxviruses: Dependence on Microsatellites

Viruses, 2015
To investigate gene loss in poxviruses belonging to the Chordopoxvirinae subfamily, we assessed the gene content of representative members of the subfamily, and determined whether individual genes present in each genome were intact, truncated, or ...
Eneida L. Hatcher, Chunlin Wang, Elliot J. Lefkowitz   +2 more
doaj   +1 more source

In Vitro Transcribed RNA-based Luciferase Reporter Assay to Study Translation Regulation in Poxvirus-infected Cells.

Journal of Visualized Experiments, 2019
Every poxvirus mRNA transcribed after viral DNA replication has an evolutionarily conserved, non-templated 5'-poly(A) leader in the 5'-UTR. To dissect the role of 5'-poly(A) leader in mRNA translation during poxvirus infection we developed an in vitro ...
Pragyesh Dhungel, Fernando Cantu, Candy Hernandez, Zhilong Yang   +3 more
semanticscholar   +1 more source

Host-derived pathogenicity islands in poxviruses

Virology Journal, 2005
Background Poxviruses are important both as pathogens and as vaccine vectors. Poxvirus genomes (150–350 kb) consist of a single linear dsDNA molecule; the two polynucleotide strands are joined by short hairpin loops.
Upton Chris, Da Silva Melissa
doaj   +1 more source

Chapparvoviruses occur in at least three vertebrate classes and have a broad biogeographic distribution [PDF]

, 2017
Chapparvoviruses are a highly divergent group of parvoviruses (family Parvoviridae) that have recently been identified via metagenomic sampling of animal faeces.
Araujo, Jansen de, Durigon, Edison Luiz, Fumagalli, Marcilio Jorge, Gifford, Robert James, Modha, Sejal, Moraes Figueiredo, Luiz Tadeu, Murcia, Pablo Ramiro, Queiroz, Luzia Helena [UNESP], Romeiro, Marilia Farignoli, Souza, William Marciel de   +9 more
core   +2 more sources

Inhibition of Poxvirus Gene Expression and Genome Replication by Bisbenzimide Derivatives

Journal of Virology, 2017
Virus infection of humans and livestock can be devastating for individuals and populations, sometimes resulting in large economic and societal impact. Prevention of virus disease by vaccination or antiviral agents is difficult to achieve.
A. Yakimovich, Moona Huttunen, B. Zehnder, L. Coulter, V. Gould, C. Schneider, M. Kopf, C. McInnes, U. Greber, J. Mercer   +9 more
semanticscholar   +1 more source