Results 131 to 140 of about 28,925 (227)
Regulation of PP1 by the Phactr family [PDF]
, 2015 PP1, Protein phosphatase 1, controls many physiological processes including cell cycle, metabolism, cell motility, and signaling since it is a critical serine threonine phosphatase in eukaryotic cells.
Patel, Zarna, Chung, Grace
core
Clinical Genetics, Volume 110, Issue 2, Page 210-226, August 2026.The Burden: Hearing loss (HL) is the most prevalent sensory disorder globally, affecting 1.5 million individuals in Brazil. The Gap: While > 150 genes are linked to HL, the genetic architecture in underrepresented populations like Brazil is poorly defined. The Problem: This lack of data limits diagnostic yield and the application of precision medicine.
Stella Diogo‐Cavassana +7 more
wiley +1 more source
International Journal of Laboratory Hematology, Volume 48, Issue 4, Page 856-865, August 2026.ABSTRACT Background Inherited platelet disorders (IPDs) are rare hematologic conditions encompassing a heterogeneous spectrum of quantitative and qualitative platelet defects, frequently associated with variable clinical phenotypes and comorbidities. Accurate diagnosis necessitates comprehensive genetic characterization, detailed clinical and bleeding ...
Silvia Ferrari +6 more
wiley +1 more source
Structuur van de ‘eiwitfosfatase PP1’-interactoren Sds22 en NIPP1 ,, [PDF]
, 2016 BACKGROUND The function of about one third of all proteins in our cells is controlled by phosphorylation by specific protein kinases. It is therefore not surprising that protein kinases are the target of many medicines. Most of these phosphorylations are
Heroes, Ewald
core
Interactomas da PP1 como meio de caracterização de funções proteicas [PDF]
, 2012 Doutoramento em BioquímicaA maioria das funções celulares, incluindo expressão de genes, crescimento e proliferação celulares, metabolismo, morfologia, motilidade, comunicação intercelular e apoptose, é regulada por interações proteína-proteína (IPP ...
Esteves, Sara Luísa de Castro
core
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes [PDF]
, 2002 Oncogenic activation of the RET receptor tyrosine kinase is common in different human cancers. We found that the pyrazolo-pyrimidine PP1 inhibited RET-derived oncoproteins with a half maximal inhibitor concentration of 80 nM.
SANTORO, MASSIMO +8 more
core +2 more sources
PharmaceuticsProtein phosphatase 1 (PP1) complexes have emerged as promising targets for anticancer therapies. The ability of peptides to mimic PP1-docking motifs, and so modulate interactions with regulatory factors, has enabled the creation of highly selective ...
Bárbara Matos +6 more
doaj +1 more source
MoleculesThis current study aims to analyze the potential bioactivities possessed by the enzymatic hydrolysates of commercial bovine, porcine, and tilapia gelatins using bioinformatics in combination with in vitro and in vivo studies.
Fenny Crista A. Panjaitan +6 more
doaj +1 more source
Фактори експериментальної еволюції організмів, 2015 Aim. Okadaic acid (OA) strongly inhibits protein serine/threonine phosphatases PP1 and PP2A/2B. In comparison with the other inhibitors the inhibitory effect of OA is strongest for PP2A, followed by PP1, and then PP2B.
Д. А. Самофалова +2 more
doaj
Maize Prolonged Prophase 1 is essential for meiotic progression in pollen mother cells
Crop JournalMeiosis, a critical process for sexual reproduction, requires precise regulation to ensure the correct progression of meiotic stages. In yeast and animals, errors in meiotic recombination and homologous chromosomes synapsis bring a surveillance mechanism
Lingling Pan +6 more
doaj +1 more source