Results 111 to 120 of about 28,925 (227)

Functional morphology and biomechanics of the locomotor apparatus in the large Late Triassic carnivore Postosuchus kirkpatricki (Archosauria: Rauisuchidae)

Journal of Anatomy, EarlyView.
A three‐dimensional model is used to analyze the locomotor biomechanics of the large Late Triassic archosaurian reptile Postosuchus kirkpatricki. The study finds that it is more uncertain than previously concluded whether it was quadrupedal or bipedal, and plantigrade or digitigrade, but it clearly had locomotor specializations including large hindlimb
John R. Hutchinson, Emily Faughey, Matthew Humpage, Tristan Dupuis, Oliver E. Demuth, Romain Pintore, Francois Clarac   +6 more
wiley   +1 more source

Caracterização do interactoma da PP1 do testículo humano [PDF]

, 2003
Protein phosphorylation is a major regulatory mechanism notably of signal transduction cascades in eukaryotic cells. Protein phosphorylation is catalysed by protein kinases and can be reversed by the action of protein phosphatases.
Fardilha, Margarida Sâncio da Cruz
core  

Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.

PLoS ONE, 2014
Innate immune sensors such as Toll-like receptors (TLRs) differentially utilize adaptor proteins and additional molecular mediators to ensure robust and precise immune responses to pathogen challenge.
Amanda M Opaluch, Monika Schneider, Chih-yuan Chiang, Quy T Nguyen, Ana M Maestre, Lubbertus C F Mulder, Ismael Secundino, Paul D De Jesus, Renate König, Viviana Simon, Victor Nizet, Graham MacLeod, Susannah Varmuza, Ana Fernandez-Sesma, Sumit K Chanda   +14 more
doaj   +1 more source

Identification of PP1 as the First Phosphatase for IRF7

Journal of Cell Signaling, 2017
Excerpt: Interferon (IFN) regulatory factor 7 (IRF7) is phosphorylated and activated in response to pathogenic infections for production of type I ...
Ning, Shunbin, Wang, Ling
openaire   +2 more sources

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Legionella effector LpPIP recruits protein phosphatase 1 to the mitochondria to induce dephosphorylation of outer membrane proteins.

PLoS Biology
Legionella pneumophila utilizes a type IVB secretion system (T4SS) to translocate over 300 effector proteins into host cells, hijacking cellular processes, including those within the mitochondrion.
Kai-Qi Yek, Evie R Hodgson, Ching-Seng Ang, Catherine S Palmer, Ann E Frazier, Hayley J Newton, Diana Stojanovski   +6 more
doaj   +1 more source

Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose

Molecules, 2019
A novel lipid inhibition peptide Leu-Leu-Val-Val-Try-Pro-Trp-Thr-Gln-Arg (PP1) (MW 1274.53 Da) was obtained from Chlorella pyenoidose using enzymatic hydrolysis, gel filtration chromatography, and LC−MS/MS.
Ruilin Zhang, Jian Chen, Xinwu Mao, Ping Qi, Xuewu Zhang   +4 more
doaj   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Sister centromere fusion during meiosis I depends on maintaining cohesins and destabilizing microtubule attachments.

PLoS Genetics, 2019
Sister centromere fusion is a process unique to meiosis that promotes co-orientation of the sister kinetochores, ensuring they attach to microtubules from the same pole during metaphase I.
Lin-Ing Wang, Arunika Das, Kim S McKim
doaj   +1 more source

PP1 Forms an Active Complex with TLRR (lrrc67), a Putative PP1 Regulatory Subunit, during the Early Stages of Spermiogenesis in Mice

PLoS ONE, 2011
Mammalian spermatogenesis is a highly regulated developmental pathway that demands dramatic rearrangement of the cytoskeleton of the male germ cell. We have described previously a leucine rich repeat protein, TLRR (also known as lrrc67), which is associated with the spermatid cytoskeleton in mouse testis and is a binding partner of protein phosphatase ...
Wang, Rong, Sperry, Ann O
openaire   +5 more sources