Results 101 to 110 of about 28,925 (227)

PP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA Pol II transcription termination

Cell Reports
Summary: The restrictor ZC3H4/WDR82 terminates antisense transcription from bidirectional promoters, but its mechanism is poorly understood. We report that ZC3H4/WDR82 immunoprecipitates with PP1 phosphatase and its nuclear targeting subunit, PP1 ...
Benjamin Erickson, Roman Fedoryshchak, Nova Fong, Ryan Sheridan, Keira Y. Larson, Anthony J. Saviola, Stephane Mouilleron, Kirk C. Hansen, Richard Treisman, David L. Bentley   +9 more
doaj   +1 more source

A single mutation in the gatekeeper residue in TgMAPKL-1 restores the inhibitory effect of a bumped kinase inhibitor on the cell cycle

International Journal for Parasitology: Drugs and Drug Resistance, 2015
Toxoplasma gondii is the causative pathogen for Toxoplasmosis. Bumped kinase inhibitor 1NM-PP1 inhibits the growth of T. gondii by targeting TgCDPK1. However, we recently reported that resistance to 1NM-PP1 can be acquired via a mutation in T.
Tatsuki Sugi, Shin-ichiro Kawazu, Taisuke Horimoto, Kentaro Kato   +3 more
doaj   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite, Plasmodium falciparum: demonstration of its essential role using RNA interference

Malaria Journal, 2002
Background Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong the causative agents of malaria.
Musiyenko Alla, Oldenburg Anja, Adams Brian, Kumar Rajinder, Barik Sailen   +4 more
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

PPP1R2 stimulates protein phosphatase-1 through stabilisation of dynamic subunit interactions

Nature Communications
Protein Ser/Thr phosphatase PP1 is always associated with one or two regulatory subunits or RIPPOs. One of the earliest evolved RIPPOs is PPP1R2, also known as Inhibitor-2.
Sarah Lemaire, Mónica Ferreira, Zander Claes, Rita Derua, Madryn Lake, Gerd Van der Hoeven, Fabienne Withof, Xinyu Cao, Elora C. Greiner, Arminja N. Kettenbach, Aleyde Van Eynde, Mathieu Bollen   +11 more
doaj   +1 more source

The IKU2/RLK7–MAPK–MINI3 signaling module controls endosperm cellularization timing to determine seed size in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The phosphorylation status of the WRKY transcription factor WRKY10/MINI3, controls the timing of endosperm cellularization in Arabiopsis, thus regulating final seed size, offering a molecular understanding that could inform future agricultural breeding strategies. ABSTRACT Seed size is a critical factor in determining crop yield.
Min Ni, Yuchen Qian, Tinggang Nong, Wangshu Mou, Niu Liu, La Yang, Dongdong Li, Huixia Shou, Juan Xu   +8 more
wiley   +1 more source

PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics [PDF]

, 2023
The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing center (MTOC) in interphase, duplicates and separates in S-G 2 forms the ...
NC DOCKS at East Carolina University, DeVaul, Nicole   +1 more
core  

Frequency of arboreality is correlated with longer hand skeletons in Gorilla: Analysis of a new skeletal sample of Bwindi mountain gorillas

Journal of Anatomy, EarlyView.
Variation in arboreality across gorilla populations is associated with systematic differences in manual digital lengths. Using a new dataset of linear metrics from the Bwindi mountain gorillas, we quantify metacarpal and phalangeal lengths in eastern and western gorilla populations across all five rays. Consistent with quantified behavioral differences,
Elliot G. Greiner, Christopher B. Ruff, Charlotte King, Aventino Nkwasibwe, Thadee Muhire, Emmanuel Tibenda, Jason S. Massey, Juho‐Antti Junno, Rowan M. Sherwood, Jean Bosco Noheri, Fred Nizeyimana, Tierra Smiley Evans, Richard Muvunyi, Dennis Babaasa, Martha M. Robbins, Shannon C. McFarlin, Tracy L. Kivell   +16 more
wiley   +1 more source

PP1-γ physically associates with TLR pathway members and TRAF6. [PDF]

, 2014
A) HEK293T cells were transfected with 3X-FLAG tagged plasmids encoding IKKγ, TRAF3, TRAF6, IKKε, and TBK1, and whole cell lysates were harvested for immunoprecipitation (IP) of endogenous PP1-γ.
Ana Fernandez-Sesma (193723), Viviana Simon (59797), Renate König (193726), Graham MacLeod (525179), Susannah Varmuza (525180), Ismael Secundino (525177), Chih-yuan Chiang (525175), Victor Nizet (49921), Amanda M. Opaluch (525173), Lubbertus C. F. Mulder (193722), Sumit K. Chanda (38512), Quy T. Nguyen (525176), Ana M. Maestre (303493), Monika Schneider (525174), Paul D. De Jesus (525178)   +14 more
core   +1 more source