Results 121 to 130 of about 28,925 (227)

Epigenetic Mechanisms Underlying Cognitive Dysfunction in Parkinson's Disease: Current Evidence and Future Prospects

Brain and Behavior, Volume 16, Issue 8, August 2026.
Epigenetic mechanismsincluding DNA methylation, histone modifications, and microRNA (miRNA) regulationmodulate gene expression without altering the DNA sequence and are increasingly implicated in the cognitive impairment associated with Parkinson's disease (PD). Environmental and molecular factors influence these epigenetic pathways, leading to altered
Fatemeh Hasani, Mohammad Ebrahim Kherad, Mohammad Sharifi Sarasyabi, Kimia Jazi, Ali Ashkbari, Payam Ahmadi, Hadise Heidarpour, Mahdi Masrour, Sina Khamaki, Rahem Rahmati, Andrei Surguchov   +10 more
wiley   +1 more source

The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme [PDF]

, 2012
SummaryRegulation of protein phosphatase 1 (PP1) is controlled by a diverse array of regulatory proteins. However, how these proteins direct PP1 specificity is not well understood.
Nichols, Scott R., Bollen, Mathieu, Beullens, Monique, Heroes, Ewald, Page, Rebecca, Peti, Wolfgang, O'Connell, Nichole   +6 more
core   +1 more source

The Wheat Intrinsically Disordered Protein TdRL1 Negatively Regulates the Type One Protein Phosphatase TdPP1

Biomolecules
Type 1 protein phosphatases (PP1s) are crucial in various plant cellular processes. Their function is controlled by regulators known as PP1-interacting proteins (PIPs), often intrinsically disordered, such as Inhibitor 2 (I2), conserved across kingdoms ...
Fatma Amor, Mariem Bradai, Ikram Zaidi, Vitor Amorim-Silva, Nabil Miled, Moez Hanin, Chantal Ebel   +6 more
doaj   +1 more source

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Cell Death & Disease
AbstractGasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely unexplored.
Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Yuqi Yan, Fushan Shi   +12 more
openaire   +3 more sources

Unveiling New Insights: Reinterpreting DES Mutation, p.Arg383His, Through a Study of an Iranian Family With Isolated Hypertrophic Cardiomyopathy, Implication for Phenotype–Genotype Correlation Analysis

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi, Farzad Kamali, Bahareh Rabbani, Mehrdad Behmanesh, Nejat Mahdieh, Mehrdad Noruzinia   +5 more
wiley   +1 more source

Competition of PP1 and SHP-1 for spinophilin. [PDF]

, 2015
(A) A diagram of spinophilin showing the PP1 binding domain [31] and the SHP-1 binding site on phosphorylated Y398 [2]. There are two tyrosine phosphorylated residues in spinophilin: Y398 and Y483.
Peisong Ma (704830), Darci C. Foote (704831), Lawrence F. Brass (417270), Andrew J. Sinnamon (704832)   +3 more
core   +1 more source

Gamma Delta T Cells in Shrimp Allergy Express a Unique Cytotoxic Cytokine Profile

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT Shellfish allergy is the most common food allergy in adults and the third most common in children. γδ T cells have been identified as playing a critical role in antigen tolerance in allergic diseases in mouse models. In humans, γδ T cells may play a regulatory role in peanut immunotherapy, and their role in shrimp allergy remains unclear.
Brenda Bin Su, Tyler Jackson, Warren Blackmon, Harold Ames, Christopher Holt, Aikaterini Anagnostou, Vibha Szafron, Sara Anvari, Hongjie Li, Carla M. Davis   +9 more
wiley   +1 more source

hScrib contains a consensus PP1-binding motif. [PDF]

, 2013
A) The schematic shows the arrangement of the functional domains on the hScrib protein, highlighting the LRR, LAPSD and PDZ domains. The putative PP1-binding site, the RVXF (the consensus sequence is K/R/H/N/S V/I/L X F/W/Y) motif is also shown, where X ...
Tomoyuki Fujii (276627), Vanitha Krishna Subbaiah (183285), Aki Yamashita (276624), Miranda Thomas (276625), Tetsu Yano (162636), Shiro Kozuma (162640), Paola Massimi (152976), Christian Kranjec (276626), Lawrence Banks (152980), Shunsuke Nakagawa (162587), Yuji Taketani (162645), Kazunori Nagasaka (276622), Takayuki Seiki (276623), Kei Kawana (162627)   +13 more
core   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

Genetic Insights Into AVP Deficiency: Identification of a Novel AVP Variant and Compilation of a Curated Catalogue of Pathogenic Variants

Clinical Genetics, Volume 110, Issue 2, Page 203-209, August 2026.
We identified a novel pathogenic AVP variant in two Danish families with autosomal dominant inheritance of symptoms of AVP deficiency. In addition, we compiled a catalogue of additionally 109 AVP variants that cause AVP deficiency and demonstrated the advantage of combining expert‐assisted curation, literature search, and online repositories to ensure ...
Jennifa Joseph, Esben Søndergaard, Sine Knorr, Jane Hagelskjær Knudsen, Søren Rittig, Jane Hvarregaard Christensen   +5 more
wiley   +1 more source